| 短期胰岛素治疗对糖尿病大鼠内脏脂肪抵抗素mRNA表达的影响 |
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| 引用本文： | 叶颖,廖鑫,黄琦,高琳.短期胰岛素治疗对糖尿病大鼠内脏脂肪抵抗素mRNA表达的影响[J].重庆医学,2011,40(19):1876-1877,1880. |
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| 作者姓名： | 叶颖 廖鑫 黄琦 高琳 |
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| 作者单位： | 遵义医学院附属医院内分泌科,贵州遵义,563003 |
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| 基金项目： | 贵州省优秀科技教育人才省长专项资金资助项目，遵义市科技计划课题资金资助项目 |
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| 摘 要： | 目的观察短期胰岛素治疗后糖尿病(DM)大鼠内脏脂肪组织抵抗素(resistin)mRNA表达及血清抵抗素水平的变化。方法采用小剂量链脲佐菌素(STZ)注射联合高糖高脂饲料喂养制备糖尿病大鼠模型,予胰岛素控制部分糖尿病大鼠血糖,设立空白对照组、血糖未控制组、血糖控制组。分别检测3组大鼠血清抵抗素水平及内脏脂肪组织抵抗素mRNA的表达;观察3组大鼠血清抵抗素、游离脂肪酸(FFA)、三酰甘油(TG)、总胆固醇(TC)水平及内脏脂肪抵抗素mRNA表达的变化。结果与空白对照组比较,血糖未控制组大鼠血清抵抗素及内脏脂肪组织抵抗素mRNA的表达显著增高(696.23±187.77)vs(538.31±142.14);(62.26±25.79)vs(10.15±12.13),P<0.05];与血糖控制组大鼠比较,血糖未控制组大鼠内脏脂肪组织抵抗素mRNA的表达亦显著增高(62.26±25.79)vs(10.45±2.99),P<0.05]。血糖控制组大鼠FFA较血糖未控制组大鼠FFA水平显著降低(0.53±0.16)vs(0.73±0.19),P<0.05],而TC水平显著增高(1.92±0.16)vs(1.22±0.38),P<0.05]。结论短期的胰岛素治疗能降低糖尿病大鼠内脏脂肪组织抵抗素mRNA的表达,可能与血糖控制后胰岛素抵抗改善及胰岛素负调节抵抗素mRNA表达有关。
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| 关 键 词： | 抵抗素 糖尿病 大鼠 胰岛素 血糖 |
Effect of short-term insulin treatment on the expression of resistin mRNA in visceral adipose in diabetic rats |
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| Ye Ying,Liao Xin,Huang Qi,Gao Lin.Effect of short-term insulin treatment on the expression of resistin mRNA in visceral adipose in diabetic rats[J].Chongqing Medical Journal,2011,40(19):1876-1877,1880. |
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| Authors: | Ye Ying Liao Xin Huang Qi Gao Lin |
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| Institution: | Ye Ying,Liao Xin,Huang Qi,Gao Lin(Department of Endocrinology,Affiliated Hospital of ZunYi Medical College,ZunYi 563003,China) |
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| Abstract: | Objective To explore the influence of insulin treatment to the serum level and the expression in visceral adipose of resistin of diabetic rats.Methods The mode of diabetic rats was prepared by injected low dosage of strep tozotocin(STZ)and fed with high sucrose and high fat diet.Blood glucose of part of diabetic rats was controlled by insulin,and separately establishing the blank group,the controlled group and the uncontrolled group according to the target levels of blood glucose.The serum resistin level an... |
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| Keywords: | resistin diabetes mellitus rats insulin blood glucose |
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