慢性胰腺炎120例相关因素分析及预防

目的探讨慢性胰腺炎(CP)发病的相关因素和预防方法。方法回顾性分析15年来收治的120例被确诊CP患者临床资料。结果流行病学资料:本组CP患者男性80例(66.7%),女性40例(33.3%);男女发病率之比为2∶1;45～55岁年龄段发病率最高。临床症状:97例(80.8%)表现为不同程度发作性或持续性上腹部疼痛,70例患者(58.3%)伴有腰背部放射痛,50例(41.7%)伴腹胀或腹泻;31例(25.8%)伴明显体质量减轻;16例(13.3%)伴糖尿病症状。相关病因:有胆道疾病史者54例(45.0%);有酗酒史者45例(37.5%)。治疗:非手术治疗68例(56.7%),外科手术治疗52例(43.3%)。结论 CP发病原因主要以胆道疾病为主,酒精因素所占比例较高。CP临床症状无特异性,治疗应结合内科、外科综合治疗;预防上45岁以上的男性应引起重视,注意少饮酒和胆道疾病的积极治疗。

Related factors and prevention of chronic pancreatitis: analysis of 120 cases

Objective To investigate the disease-related factors and prevention methods of chronic pancreatitis（CP）.Methods The clinical data of 120 cases of CP diagnosed in our hospital during the past 15 years were analyzed retrospectively.Results Epidemiology： of the 120 patients,80 were male（66.7%） 40 were female（33.3%）;male to female ratio was 2∶1.The highest incidence of CP was observed in 45～55 age group.Clinical symptoms： varying degrees of paroxysmal or persistent upper abdominal pain occurred in 97 patients（80.8%）,lower back radiating pain in 70（58.3%）,bloating or diarrhea in 50（41.7%）;significantly reduced body weight in 31（25.8%）;and symptoms of diabetes in 16（13.3%）.Related causes： 54 patients（45.0%） had history of biliary tract diseases,45（37.5%） had history of alcohol abuse.Treatment： non-surgical treatment in 68 patients（56.7%）,surgical treatment in 52 patients（43.3%）.Conclusion CP is mainly related to biliary tract diseases in our country.The percentage of alcohol-induced CP is increasing.The clinical symptoms of CP are not specific.The prevention of CP should be focused on the men over 45,and limited drinking and active treatment of biliary tract disease are advised.