艾司西酞普兰与文拉法辛治疗首发抑郁症对照研究

目的 探讨艾司西酞普兰与文拉法辛缓释剂治疗首发抑郁症的临床疗效和安全性.方法 将80例抑郁症患者随机分为两组,每组40例,研究组口服艾司西酞普兰治疗,对照组口服文拉法辛缓释胶囊治疗,观察6周.于治疗前及治疗第1周、2周、4周、6周末采用汉密顿抑郁量表评定临床疗效,副反应量表评定不良反应.结果 治疗1周末起,两组汉密顿抑郁量表总分均较治疗前有显著下降(P＜0.01),治疗各时段两组汉密顿抑郁量表总分及减分率差异均无显著性(P＞0.05);治疗6周末,研究组痊愈率52.63%、有效率为81.58%,对照组分别为54.05%、78.38%,两组差异无显著性(χ2=0.015、0.120,P＞0.05).两组不良反应均轻微,多出现在用药初期,随着时间的延长均可减轻或缓解,研究组恶心、多汗不良反应发生率显著低于对照组(P＜0.05或0.01),其他不良反应发生率两组差异均无显著性(P＞0.05).结论 艾司西酞普兰与文拉法辛缓释剂治疗首发抑郁症疗效显著,起效快,但艾司西酞普兰安全性更高,依从性更好.

A control study of escitalopram vs.venlafaxine in first-episode depression

Objeefive To explore the efficacy and safety of escitalopram vs. venlafaxine extended release （XR） in the treatment of first-episode depression. Methods Eighty patients were randomly divided into two groups of 40 ones each, research group took orally escitalopram and control group did venlafaxine XR 6 weeks. Clinical efficacies were assessed with the Hamilton Depression Scale （HAMD） and adverse reac- tions with the Treatment Emergent Symptom Scale （TESS） before treatment and at the end of the 1st , 2nd , 4th and 6th week. Results The HAMD scores of both groups lowered more significantly since the end of the 1st week compared with pretreatment （P〈0.01）, there were no significant differences in the HAMD total scores and score-reducing rates in each period between two groups （P〈0.05） ; at the end of the 6th week, healing and effective rate were 52. 63% and 81.58% in the research and 54.05% and 78.38% in the control group, which showed no significant differences （x2 = 0.015,0. 120, P〉0.05）. Adverse reactions of both groups were mild, emerged mainly in the initial stage of treatment and could lessen or relieve with treatment; incidences of nausea and hyperhidrosis were significantly lower in the research than in the control group （P〈0.05 or 0.01） and there were no significant differences in the incidences of other adverse reactions （P〉0.05）. Conclusion Both escitalopram and venlafaxine XR are effective and take effect rap- idly in the treatment of first episode depression, but the former has higher safety and better compliance.