小容量复苏对失血性休克兔血液动力学及血气的影响

目的探讨小容量复苏对失血性休克兔早期血流动力学及血气的影响。方法分别给予4 mL/kg高渗盐水（HS组）和4 mL/kg高渗盐水加羟乙基淀粉溶液（HSS组）对失血性休克犬进行容量复苏,并以失血量3倍的等渗盐水（NS组）作对照,观察复苏后早期血流动力学及血气的变化。结果3种溶液均能改善失血性休克兔复苏的早期血流动力学及血气指标,30 min后高渗盐水、HSS及等渗盐水容量指标下降,血流动力学下降,其中高渗盐水及等渗盐水及等渗盐水下降最为明显。结论小容量高渗盐水在失血性休克模型中的复苏效果与等渗盐水类似,小容量高渗盐水加羟乙基淀粉容量的效果优于前两组。

Effects of small volume resuscitation on hemodynamics and blood gas values in rabbits model of hemorrhagic shock

Objective：To investigate the effects of small volume resuscitation on hemodynamics and blood gas values in rabbits model of hemorrhagic shock.Methods： Twenty-four rabbits were hemorrhaged to hold mean arterial blood pressure at 45～55 mmHg for 45 minutes,and then divided into three groups.HS group（n = 8）were resuscitated with 4 mL / kg of hypertonic saline solution,HSS group（n = 8）resuscitated with 4 mL / kg of hypertonic starch solution,NS group（n = 8） resuscitated with normal saline.Hemodynamics and blood gas values were detected after fluid resuscitation.Results： All three kinds of solutions could improve the hemodynamics and blood gas values in the early stage.But after 30 minutes,the values of capacity and,hemodynamics of the HS group,HSS group and NS group began to decrease.Conclusion： The resuscitation effect of hypertonic saline solution was similar as normal saline,and the effect of hypertonic starch solution was better than the former kinds of saline solution.