尼群地平对体外循环中红细胞钙及变形能力的影响

研究体外循环中钙桔抗剂对红细胞的影响。方法：对４０例非紫绀型先天性心脏病患者，按随机配对原则分为对照组（Ｃ组）与尼群地平组（Ｎ组）。测定体外循环期红细胞钙（Ｅ－Ｃａ２＋）、Ｃａ２＋，Ｍｇ２＋－ＡＴＰ酶与Ｎａ＋，Ｋ＋－ＡＴＰ酶活性、滤过指数（ＩＦ）、平均体积（ＭＣＶ）。结果：Ｃ组体外循环中Ｅ－Ｃａ２＋、ＩＦ、ＭＣＶ进行性增加，Ｃａ２＋，Ｍｇ２＋－ＡＴＰ酶与Ｎａ＋，Ｋ＋－ＡＴＰ酶活性下降，Ｅ－Ｃａ２＋与ＩＦ、ＭＣＶ直线正相关，而Ｎ组上述各项指标变化均明显减轻（Ｐ＜０．０５）。结论：结果提示体外循环中尼群地平对红细胞具有良好的保护作用。

Affect of Nitrendipine for Erythrocyte Calcium and Erythrocyte Deformability during Cardiopulmonary Bypass

To learn the relationship between erythrocyte and Calcium antagonists for erythrocytes during cardiopulmonary bypass (CPB ). Methods:Fourly patients with noncynotjc congenital heart disease were randomlymatched-fair divided into two groups: Control group (Group C) and nitrendipme group(Group N). The erythrocytes Calcium content(E Ca2 ), activities ofCa2 , Mg2 -ATPase and Na , K -ATPase, index filtration (IF), mean ocrpuscular volume(MCV) were measured. Results: In Group C, E-Ca2 , IF,MCV increased gradually, activities of Ca2 , Mg2 -ATPase and Na K ATPase were reduced. The E-Ca2 4 was closely related to IF, MCV(T=0. 79,0.85, respectively). But in Group N, all of above parameters were improved.Conclusion: These results suggest that the Calcium overload of erythrocytes isan important factor of reduced red cell beformability during CPB. Utilizing mtrendipine before operation is a more effective measure for erythrocytes protecnon in CPB.