苯并硒唑酮-多糖衍生物的合成及生物活性研究

目的 研究有机硒-多糖衍生物的人工合成方法及其生物活性。方法 以依布硒（Ebselen）的含硒基团为母核，对苯并硒唑酮-多糖衍生物进行化学合成。结果 合成了4种苯并硒唑酮-多糖衍生物，所用多糖有3种为海洋来源糖类，并测定了其中2种硒多糖对4种肿瘤细胞的增殖抑制活性，抑制率均超过80%。为苯并硒唑酮-多糖衍生物的合成及其活性研究提供了参考。

Study on the synthesis and bioactivities of benzoselenidone-polysaccharide derivatives

Objective The synthesis and biological activities of organoselenium-polysaccharide derivatives. Methods Benzoselenidone-polysaccharide derivatives were synthesized by using the selenium-containing group of Ebselen as parent nucleus. Results Four benzoselenidone-polysaccharide derivatives were synthesized, among them, three polysaccharide moiety derived from marine resource. Two selenium-polysaccharides exibited potent inhibitory on the proliferation against four tumor cell lines with the inhibitory rates over 80%. This study provides reference for the synthesis and bioactivity of benzoselenidone-polysaccharide derivatives.