| 苯并硒唑酮-多糖衍生物的合成及生物活性研究 |
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| 引用本文： | 薛亮,墨自营,张之金,江涛.苯并硒唑酮-多糖衍生物的合成及生物活性研究[J].中国海洋药物,2022,41(3):64-68. |
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| 作者姓名： | 薛亮 墨自营 张之金 江涛 |
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| 作者单位： | 中国海洋大学医药学院,中国海洋大学医药学院,中国海洋大学医药学院,中国海洋大学医药学院 |
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| 摘 要： | 目的 研究有机硒-多糖衍生物的人工合成方法及其生物活性。方法 以依布硒（Ebselen）的含硒基团为母核，对苯并硒唑酮-多糖衍生物进行化学合成。结果 合成了4种苯并硒唑酮-多糖衍生物，所用多糖有3种为海洋来源糖类，并测定了其中2种硒多糖对4种肿瘤细胞的增殖抑制活性，抑制率均超过80%。为苯并硒唑酮-多糖衍生物的合成及其活性研究提供了参考。
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| 关 键 词： | 有机硒-多糖衍生物 依布硒 硒多糖 |
| 收稿时间： | 2021/5/14 0:00:00 |
| 修稿时间： | 2021/8/5 0:00:00 |
Study on the synthesis and bioactivities of benzoselenidone-polysaccharide derivatives |
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| Xue Liang,Mo Ziying,Zhang Zhijin and Jiang Tao.Study on the synthesis and bioactivities of benzoselenidone-polysaccharide derivatives[J].Chinese Journal of Marine Drugs,2022,41(3):64-68. |
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| Authors: | Xue Liang Mo Ziying Zhang Zhijin and Jiang Tao |
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| Institution: | School of Medicine and Pharmacy,Ocean University of China,School of Medicine and Pharmacy,Ocean University of China,School of Medicine and Pharmacy,Ocean University of China,School of Medicine and Pharmacy,Ocean University of China |
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| Abstract: | Objective The synthesis and biological activities of organoselenium-polysaccharide derivatives. Methods Benzoselenidone-polysaccharide derivatives were synthesized by using the selenium-containing group of Ebselen as parent nucleus. Results Four benzoselenidone-polysaccharide derivatives were synthesized, among them, three polysaccharide moiety derived from marine resource. Two selenium-polysaccharides exibited potent inhibitory on the proliferation against four tumor cell lines with the inhibitory rates over 80%. This study provides reference for the synthesis and bioactivity of benzoselenidone-polysaccharide derivatives. |
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| Keywords: | organoselenium-polysaccharide derivatives Ebselen selenium-polysaccharide |
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