| 海牡方对环磷酰胺所致小鼠造血功能损伤的保护作用 |
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| 引用本文： | 马伟平,王珊珊,李琳娜,刘明,胡淑曼,袁守军,刘红兵. 海牡方对环磷酰胺所致小鼠造血功能损伤的保护作用[J]. 中国海洋药物, 2022, 41(3): 75-78 |
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| 作者姓名： | 马伟平 王珊珊 李琳娜 刘明 胡淑曼 袁守军 刘红兵 |
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| 作者单位： | 中国海洋大学海洋药物教育部重点实验室 医药学院,军事医学研究院辐射医学研究所药物研究室,军事医学研究院辐射医学研究所药物研究室,中国海洋大学海洋药物教育部重点实验室 医药学院,中国海洋大学海洋药物教育部重点实验室 医药学院;青岛海洋生物医药研究院,军事医学研究院辐射医学研究所药物研究室,中国海洋大学海洋药物教育部重点实验室 医药学院;青岛海洋科学与技术试点国家实验室海洋药物与生物制品功能实验室;青岛海洋科学与技术试点国家实验室海洋药物与生物制品功能实验室 |
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| 基金项目： | 山东省重大科技创新工程专项蓝色药库技术创新工程项目（No. 2018SDKJ0405），青岛市海洋生物医药科技创新中心项目（No. 2017-CXZX01-3-10） |
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| 摘 要： | 目的 研究中药复方制剂海牡方对小鼠造血功能损伤的保护作用。方法 单次尾静脉给予大剂量(250 mg/kg)的环磷酰胺建立小鼠白细胞减少症模型；灌胃给予不同剂量的海牡方受试物,观察对小鼠血细胞、骨髓细胞DNA含量等的影响。结果 海牡方可以促进模型小鼠的白细胞、红细胞及血小板计数水平的恢复(p<0.01),缓解骨髓细胞DNA含量的降低。结论 海牡方能促进环磷酰胺模型小鼠造血机能的恢复,对环磷酰胺所致骨髓损伤具有一定的保护作用。
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| 关 键 词： | 海牡方 白细胞减少症 环磷酰胺 造血功能 |
| 收稿时间： | 2021-05-19 |
| 修稿时间： | 2021-05-25 |
Protective effects of Haimufang Decoction on hematopoietic damage induced by cyclophosphamide in mice |
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| MA Wei-ping,WANG Shan-shan,Li Lin-n,LIU Ming,HU Shu-man,Yuan Shou-jun and Liu Hong-bing. Protective effects of Haimufang Decoction on hematopoietic damage induced by cyclophosphamide in mice[J]. Chinese Journal of Marine Drugs, 2022, 41(3): 75-78 |
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| Authors: | MA Wei-ping WANG Shan-shan Li Lin-n LIU Ming HU Shu-man Yuan Shou-jun Liu Hong-bing |
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| Affiliation: | Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Department of Oncology Pharmacology,Institute of Radiation and Radiation Medicine,Academy of Military Medical Sciences,Beijing,Department of Oncology Pharmacology,Institute of Radiation and Radiation Medicine,Academy of Military Medical Sciences,Beijing,Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Department of Oncology Pharmacology,Institute of Radiation and Radiation Medicine,Academy of Military Medical Sciences,Beijing,Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy,Ocean University of China;SLaboratory of Marine Drugs and Biological Products,Pilot National Laboratory for Marine Science and Technology |
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| Abstract: | Objective To investigate the protective effect of the Chinese medicine formula, Haimufang decoction (HMF), on the damage of hematopoietic function in mice. Methods Leukopenia model was established by single administration of high dose (250 mg/kg) of cyclophosphamide in tail vein in mice. The effects of different doses of HMF by intragastrical administration on blood cells and DNA content of bone marrow cells were evaluated. Results HMF could promote the recovery of white blood cells, red blood cells and platelet count (P <0.01), and alleviate the decrease of bone marrow cell DNA content in model mice. Conclusion HMF could promote the recovery of hematopoietic function in model mice and had certain protective effect on the bone marrow injury caused by cyclophosphamide. |
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| Keywords: | Haimufang decoction (HMF) aleukemia cyclophosphamide hematopoietic function |
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