| 慢性肾小球疾病尿液中纤溶酶原激活物抑制物及细胞外基质成分研究 |
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| 引用本文： | 朱辟疆,韦先进,刘建忠,江丽萍.慢性肾小球疾病尿液中纤溶酶原激活物抑制物及细胞外基质成分研究[J].临床内科杂志,2001,18(2):145-146. |
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| 作者姓名： | 朱辟疆 韦先进 刘建忠 江丽萍 |
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| 作者单位： | 江苏省中西医结合肾脏病研究中心 |
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| 摘 要： | 目的：探讨慢性肾小球疾病者尿中细胞外基质成分的改变。方法对105例慢性肾小球疾病患者尿中纤溶酶原激活性抑制、Ⅳ型胶原及层粘蛋白进行测定。结果与健康人比较，各型肾小球疾病中纤溶酶原激活物抑制剂（PAI）均明显增高（P＜0．05），慢性衰期及终末期肾病尿Ⅳ型胶原明显降低（P＜0．05），尿层粘蛋白亦明显降低（P＜0．05），PAI与SCr显著正相关（P＜0．05）；与Ⅳ型胶原显著负相关（P＜0．05）。结论慢性肾小球疾病尿中PAI均增高，且随肾功能损害加重增高更明显，在尿Ⅳ型胶原及层粘蛋等细胞外基质成分反而降低。
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| 关 键 词： | 慢性紧小球疾病 纤溶酶原激活物抑制物 细胞外基质成分 Ⅳ型胶原 纤维连接蛋白 |
| 文章编号： | 1001-9057(2001)02-0145-02 |
| 修稿时间： | 2000年7月11日 |
Study on urinary plasminogen activator inhibitor and extracellular matrix ingredient in chronic glomerular disease |
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| ZHU Pijing,WEI Xianjin,LIU Jianzhong,et al..Study on urinary plasminogen activator inhibitor and extracellular matrix ingredient in chronic glomerular disease[J].Journal of Clinical Internal Medicine,2001,18(2):145-146. |
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| Authors: | ZHU Pijing WEI Xianjin LIU Jianzhong |
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| Institution: | ZHU Pijing,WEI Xianjin,LIU Jianzhong,et al.Jiangsu Integrated Traditional Chinese and Western Medical Research Center of Nephrology,Zhenjiang 212002,China |
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| Abstract: | Objective To evaluated the change of urinary extracellular matrix (ECM) ingredient in patients with chronic glomerular disease. Methods The plasminogen activator inhibitor(PAI), Ⅳ-col-lagen (Ⅳ-C) and laminin (LN) were measured in 105 patients. Results The levels of urinary PAI in were significantly higher than those of normal controls (P＜0.05), the level of Ⅳ-C decreased in patients with chronic renal failure patients while the levels of Ⅳ-C and LN decreased in the patients with end state of renal failure (ESRD) .PAI has a positive correlation with Scr(P＜0.05) and negative correlation with Ⅳ-C(P＜0.05). Conclusion The level of PAI increase in patients with chronic glomerular disease and it increases more significant with the deterioration of renal function, while the level of Urinary Ⅳ-C and LN decrease. |
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| Keywords: | Chronic glomerular disease Plasminogen activator inhibitor Extracellular matrix Collagen IV Laminin |
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