| MK-801对大鼠感染性脑水肿的保护作用及机制探讨 |
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| 引用本文： | 尹飞,杨于嘉,虞佩兰,毛定安,陶永光. MK-801对大鼠感染性脑水肿的保护作用及机制探讨[J]. 中国现代医学杂志, 2000, 10(1): 3-4 |
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| 作者姓名： | 尹飞 杨于嘉 虞佩兰 毛定安 陶永光 |
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| 作者单位： | 湖南医科大学附属湘雅医院儿科,长沙,410008 |
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| 基金项目： | 国家自然科学基金资助! (基金项目编号39470233) |
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| 摘 要： | 目的：了解ＭＫ－８０１对大鼠感染性脑水肿是否具有保护作用及可能的作用机制。方法：ＥＬＩＳＡ法与Ｇｒｉｅｓｓ法分别测大鼠感染性脑水肿模型脑组织匀浆中ＩＬ－１β，ＴＮＦα和ＮＯ含量。结果：ＭＫ－８０１预处理后能显著降低ＰＢ组大鼠的脑含水量，钠离子含量，ＩＬ－１β，ＴＮＦα及ＮＯ含量，增加钾离子含量。
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| 关 键 词： | 脑水肿 MK－801 细胞因子 神经保护 动物模型 |
A Siudy on the Protective Effect and lts Mechanism of MK -801 on infective Encephaledema of Rats |
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| Yi Fei,Yang Yujia,Yu Peilan,et al.. A Siudy on the Protective Effect and lts Mechanism of MK -801 on infective Encephaledema of Rats[J]. China Journal of Modern Medicine, 2000, 10(1): 3-4 |
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| Authors: | Yi Fei Yang Yujia Yu Peilan et al. |
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| Affiliation: | Yi Fei,Yang Yujia,Yu Peilan,et al. Department of Pediatrics,Affiliated Xiangya Hospital of Hunan Medical University,Changsha,Hunan 410008 |
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| Abstract: | Objective:To investigate the protective effect and its possible mechanism of action infective encephaledema of rats.Methods:Thecontents of IL-1B,TNFa and NO in the brain tissue homogenate of the rat model of infective encephaledema were measured by the methods of ELISA and Griess respectively.Results:The pretreatment of MK-801 could significantly reduce the cerebral content of water,sodion,IL-1B,TNFa and NO,significanly increase potassium ion all together. Conclusions:MK-801 acts the part of protection on infective encephaledema of rats.The possible mechanism of action may lie in decreasing the production of IL-1B,TNFa and NO after having blocked NMDA receptor. |
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| Keywords: | Encephaledema MK-801 Cellular Factor Nerve Protection |
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