| 血卟啉衍生物不同途径给药并光照小鼠移植瘤的形态观察及DNA定量测定 |
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| 引用本文： | 黄卓垣,丁华野,单宝珍,郭友池,陈景藻,吴必伦,李学荣. 血卟啉衍生物不同途径给药并光照小鼠移植瘤的形态观察及DNA定量测定[J]. 医学争鸣, 1986, 0(3) |
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| 作者姓名： | 黄卓垣 丁华野 单宝珍 郭友池 陈景藻 吴必伦 李学荣 |
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| 作者单位： | 第四军医大学病理解剖教研室(黄卓垣，丁华野，单宝珍)，第四军医大学附属一院理疗科(郭友池，陈景藻，吴必伦)，第四军医大学电镜室(李学荣) |
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| 摘 要： | 用光镜、电镜和扫描图像分析仪,对比观察静脉注射与肿瘤局部注射血卟啉衍生物并光照,小鼠皮下型H_(22)肝癌细胞的形态学和DNA含量的改变。结果显示,两种给药法并光照对瘤细胞均有杀伤效应,后者更为显著。本实验为治疗某些体表肿瘤采用局部注药光照法,减少全身用药量和毒副作用提供了形态学依据。
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| 关 键 词： | 血卟啉衍生物 光辐照 小鼠H_(22)肝癌 DNA含量 |
Morphological Obervation and DNA Quantitative Analysis of Murine H_(22) Hepatoma after Being Injected with HPD in Different Pathway and Lighted |
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| Huang Zhuoyuan,et al. Morphological Obervation and DNA Quantitative Analysis of Murine H_(22) Hepatoma after Being Injected with HPD in Different Pathway and Lighted[J]. Negative, 1986, 0(3) |
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| Authors: | Huang Zhuoyuan et al |
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| Affiliation: | Department of Pathology |
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| Abstract: | With light and electron microscopy and texture analysis system(TAS), the morphologic changes and the content of DNA after injecting HPD in different pathway and lighting on mice H22 hepatoma were observed. This study showed that HPD injected intravenously and tumor locally and red-light irradiation could result in obvious injury of tumor cells, especially by tumor local injection and light irradiation. In order to reduce various side-effects, tumor local injection and light may be used in clinical treatment. This article has provided morphological basis as a reference. |
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| Keywords: | hematoporphyrin derivative (HPD) light irradiation mice hepatoma DNA content |
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