| 中国和日本部分地区TT病毒的检出率及基因亚型 … |
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| 引用本文： | 刘卫东,波田寿一. 中国和日本部分地区TT病毒的检出率及基因亚型 …[J]. 中华实验和临床病毒学杂志, 2000, 14(2): 169-172 |
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| 作者姓名： | 刘卫东 波田寿一 |
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| 作者单位： | [1]汕头大学医学院第二附属医院中心实验室 [2]日本国兵库医科大学第三内科 |
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| 摘 要： | 目的 比较中国及日本部分地区ＴＴ病毒（ＴＴＶ）感染情况及基因亚型分布特征。方法 采用半巢式－聚合酶链反应（Ｓｅｍｉ－ｎｅｓｔｅｄ ＰＣＲ）检测中国和日本部分慢性丙型肝炎患者及正常人血标本中的ＴＴＶ感染情况，并对阳性产物片段直接进行序列分析。结果 发现中国部分正常人群ＴＴＶ感染率为６４％；慢性丙型肝炎患者ＴＴＶ感染率中国国为６８％，日本为４９．１％，基因亚型分布中国ＴＴＶ Ｇ２ａ＋２ｂ亚型占６０％，
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| 关 键 词： | 肝炎病毒 TTV 聚合酶链反应 碱基序列 检出率 |
| 修稿时间： | 2000-01-24 |
High prevalence of TT virus (TTV) infection and gene subtype analysis between Japanese and Chinese |
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| LIU Weidong,HADA Toshikazu,XU Hui,et al.. High prevalence of TT virus (TTV) infection and gene subtype analysis between Japanese and Chinese[J]. Chinese journal of experimental and clinical virology, 2000, 14(2): 169-172 |
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| Authors: | LIU Weidong HADA Toshikazu XU Hui et al. |
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| Affiliation: | Common Laboratory of Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China. |
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| Abstract: | Objective To compare the infection rates and gene subtypes of TTV between Japanese and Chinese.Methods TTV was detected by a semi nested PCR. The positive samples were sequenced directly.Results Infection rate of TTV in normal Chinese was 64%, but in the patients suffered from chronic C hepatitis, the infection rates were 68% in Chinese and 49.1% in Japanese. The gene subtype of TTV Gla 1b in Chinese was 40%, G2a 2b 60%; in Japanese TTV G1a 1b was 78.6%, G2a 2b 21.4%.Conclusion There were high infection rates of TTV in Chinese and Japanese. The gene subtype distribution of TTV had some difference between Chinese and Japanese. |
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| Keywords: | Hepatitis virus Polymerase chain reaction Base sequence Gene |
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