| 神经生长因子在糖尿病足创面组织中的表达 |
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| 引用本文： | 李炳辉,邹新华,杨鸿,罗颖琪,李春亭,冯自波,李恭驰,籍胤玺.神经生长因子在糖尿病足创面组织中的表达[J].中华损伤与修复杂志,2010(5):22-24. |
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| 作者姓名： | 李炳辉 邹新华 杨鸿 罗颖琪 李春亭 冯自波 李恭驰 籍胤玺 |
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| 作者单位： | [1]华中科技大学同济医学院附属梨园医院创面修复科,武汉430030 [2]华中科技大学同济医学院,武汉430030 |
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| 摘 要： | 目的研究神经生长因子(NGF)及其高亲和性的酪氨酸激酶-A受体(TrkA)在糖尿病足创面组织中的表达。方法 收集糖尿病足创面组织标本作为对照组,正常人皮肤及皮下软组织标本作为正常组,采用免疫组化的方法观察神经生长因子(NGF)及其高亲和性的TrkA受体的表达,酶联免疫吸附测定法(ELISA)测定NGF的含量。结果 对照组NGF含量为(66.299±10.204)pg/ml,与正常组NGF含量(35.015±4.671)pg/ml相比,差异有统计学意义(P=0.010)。结论 NGF及其高亲和性的TrkA受体在糖尿病足创面组织中表达的变化可能参与了创面的发生发展,是糖尿病足创面修复的影响因素之一。
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| 关 键 词： | 神经生长因子 酪氨酸激酶-A受体 糖尿病足 |
Expression of nerve growth factor in the wound tissue of diabetic foot patients |
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| Institution: | LI Bing-hui,ZOU Xin-hua,YANG Hong,LUO Yin-qi,LI Chun-ting,FENG Chun-ting,FENG Zi-bo,LI Gong-chi,JI Ying-xi Wound Repair Division,Liyuan Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430077,China |
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| Abstract: | Objective To study the expression of nerve growth factor（NGF） and its high-affinity tyrosine kinase receptor-A（TrkA） in the wound tissue of diabetic foot patients.Methods Diabetic foot wound samples and normal human subcutaneous tissue samples were collected,expression of NGF and its high-affinity receptor TrkA were observed by immunohistochemistry,and content of NGF was detected by enzyme-linked immunosorbent assay（ELISA）.Results The content of NGF in diabetic foot wound samples was significantly higher than that in normal human subcutaneous tissue samples（P=0.010）.Conclusion The change of NGF and its high-affinity receptor TrkA expression in the wound tissue of diabetic foot patients may involve in the development of the wounds,which is a factor affecting the diabetic foot wound healing. |
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| Keywords: | Nerve growth factor Tyrosine kinase receptor-A Diabetic foot |
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