High level of FOXC1 expression is associated with poor prognosis in pancreatic ductal adenocarcinoma |
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| Authors: | Lei Wang Feng Gu Chao-Ying Liu Run-Jie Wang Jiang Li Jun-Ying Xu |
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| Affiliation: | 1. Department of General Surgery, First People’s Hospital of Changshu City, Changshu Hospital Affiliated to Soochow University, Changshu, 215500, Jiangsu Province, China
2. Department of Oncology, Wuxi People’s Hospital Affiliated to Nanjing Medical University, No.299, Qingyang Road, Wuxi, 214023, China
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| Abstract: | Accumulating evidence for overexpression of FOXC1 in various types of human cancer suggests that it plays a key role in tumor biology. However, little is known about the function of FOXC1 in pancreatic ductal adenocarcinoma (PDA). This study was to investigate the expression profile of FOXC1 in PDA and its clinical significance. We detected the expression profile of FOXC1 mRNA and protein in PDA tissue and in corresponding normal tissue by quantitative reverse-transcriptase polymerase chain reaction and western blotting. Immunohistochemistry was also used in the detection of FOXC1 protein expression. The clinicopathological implications of these proteins were analyzed statistically. Survival analysis was performed to assess prognostic significance. FOXC1 mRNA was overexpressed in PDA tissue when compared with corresponding normal tissue, so was FOXC1 protein. The overexpression of FOXC1 was significantly associated with the degree of clinical stage (p?p?=?0.002), and lymph node metastases (p?
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