| HPLC法同时测定复方萘酚喹片中磷酸萘酚喹和甲氧苄啶的含量 |
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| 引用本文： | 张玉英,潘锡强. HPLC法同时测定复方萘酚喹片中磷酸萘酚喹和甲氧苄啶的含量[J]. 中国现代应用药学, 2000, 17(6): 472-474 |
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| 作者姓名： | 张玉英 潘锡强 |
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| 作者单位： | 广州市药品检验所,广州,510160 |
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| 摘 要： | 目的：建立同时测定复方萘酚喹片中磷酸萘酚喹和甲氧苄啶含量的方法。方法：高效液相色谱法。固定相为十八烷基硅烷键合硅胶；流动相为乙腈－0．25％二乙胺（30：70，混合后用磷酸调pH至2．5）；检测波长271nm。结果：线性范围：磷酸萘酚喹75．9－227．8μg/ml,r=0.9999，甲氧苄啶26．7－80．2μg/mol,r=0.9999；方法回收率；磷酸萘酚喹100．5％，RSD 0．3％，n=6,甲氧苄啶99．7％，RSD0．7％，n=6。结论：该方法操作简便，结果准确，适用于该制剂的含量测定。
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| 关 键 词： | HPLC 复方萘酚喹片 磷酸萘酚喹 甲氧苄啶 |
Simultaneos determination of naphthoquine phosphate and trimethoprim in compound naphthoquine tablets |
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| Zhang Yuying(Zhang YY,Pan Xiqiang(Pan XQ. Simultaneos determination of naphthoquine phosphate and trimethoprim in compound naphthoquine tablets[J]. The Chinese Journal of Modern Applied Pharmacy, 2000, 17(6): 472-474 |
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| Authors: | Zhang Yuying(Zhang YY Pan Xiqiang(Pan XQ |
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| Affiliation: | Zhang Yuying(Zhang YY),Pan Xiqiang |
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| Abstract: | OBJECTIVE:To establish the HPLC method for simultaneos determination of naphthoquine phosphate and trimethoprim in compound naphthoquine tablets.METHODS:The HPLC method was developed under the following conditions:column,C18,the mobile phase was acetonitr |
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| Keywords: | HPLC compound naphthoquine tablets naphthoquine phosphate trimethoprim |
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