| miR-337-3p对胃癌细胞SGC7901中HPSE表达的调控及其对细胞增殖的影响 |
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| 引用本文： | 潘国友,董康迪,谢德天,彭利盼.miR-337-3p对胃癌细胞SGC7901中HPSE表达的调控及其对细胞增殖的影响[J].中国现代普通外科进展,2019(4):259-261,265. |
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| 作者姓名： | 潘国友 董康迪 谢德天 彭利盼 |
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| 作者单位： | 山东省肿瘤防治研究院妇科肿瘤四病区;山东大学附属省立医院胃肠外科 |
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| 基金项目： | 山东省自然科学基金(ZR2015PH024);山东省重点研发计划项目(2017GSF221003 |
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| 摘 要： | 目的:探讨miR-337-3p对胃癌细胞SGC7901中HPSE表达的调控作用及其对细胞增殖的影响。方法:miR-337-3p mimics转染SGC7901细胞后,应用RT-PCR、Western blot检测其对miR-337-3p表达水平的影响及其对HPSE表达的影响;荧光素酶实验检测转染细胞中HPSE 3’-UTR荧光素酶活性;CCK-8测定细胞增殖的影响。结果:上调miR-337-3p可以抑制HPSE的表达、降低HPSE 3’-UTR启动子荧光素酶活性,并可抑制胃癌细胞增殖。结论:miR-337-3p可以通过下调HPSE的表达抑制胃癌细胞SGC7901增殖。
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| 关 键 词： | MiR-337-3p HPSE 胃癌 增殖 |
MiR-337-3p is involved in proliferation in gastric cancer cells SGC7901 via regulating HPSE |
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| PAN Guo-you,DONG Kang-di,XIE De-tian,PENG Li-pan.MiR-337-3p is involved in proliferation in gastric cancer cells SGC7901 via regulating HPSE[J].Chinese Journal of Current Advances in General Surgery,2019(4):259-261,265. |
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| Authors: | PAN Guo-you DONG Kang-di XIE De-tian PENG Li-pan |
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| Institution: | (Ward 4 of Gynaecological Tumors,Shandong Institute of cancer prevention and control(Jinan 250117,China);Department of Gastrointestinal Surgery,Shandong Provincial Hospital affilicated to Shandong Universtity(Jinan 250021,China)) |
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| Abstract: | PAN Guo-you;DONG Kang-di;XIE De-tian;PENG Li-pan(Ward 4 of Gynaecological Tumors,Shandong Institute of cancer prevention and control(Jinan 250117,China);Department of Gastrointestinal Surgery,Shandong Provincial Hospital affilicated to Shandong Universtity(Jinan 250021,China)) |
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| Keywords: | MiR-337-3p HPSE Gastric cancer Proliferation |
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