正常妊娠中内皮素的测定

用放射免疫法测定了１１０例正常妊娠妇女、２３例正常非孕妇女外周血，２０例正常阴道分娩妇女外周血和脐血，１２例部宫产孕妇胎盘、胎膜、蜕膜、子宫肌层组织外外周血中内皮素－１（ＥＴ－１）的含量。结果：与非孕期比较，正常妊娠期血浆ＥＴ－１明显下降，以孕中期最为显著；临产后血浆ＥＴ－１显著升高，与非孕期相比无显著差异。妊娠后至临产前及非孕期妇女血浆ＥＴ－１与平均动脉压均呈正相关。脐ＥＴ－１为外周血的３．７和

DETERMINATIONS OF ENDOTHELIN IN NORMAL PREGNANCY

We measured Plasma endothelin 1 (ET-1) concentrations in 110 normal pregnant women (NPW) and 23 normal non pregnant women (NNPW), that of maternal venous (MV), umbilical artery (UA) and umbilical vein (UV) in 20 normal parturient women at term (vaginal), and the tissue ET-1 concentrations of the placenta, fetal membrane, decidua and myometrium in 12 normotensive women at term (caesarean section) by radioimmunoassay. Results: compared with NNPW, plasma ET-1 levels were significantly decreased in NPW, and the lowest levels was in the second trimester. The plasma ET-1 levels were significantly increased in the labour, and were similar to that in NNPW. There were significant positive correlations between plasma ET-1 levels and mean arterial pressure in NNPW and NPW during the first, second and third trimester. UA and UV (ET -1) were 3.7 and 6.5 times of MV (ET 1), the UV (ET 1) was higher than UA (EF-1) significantly. The ET-1 concentrations of fetal membrane, placenta, decidua and myometrium were 38, 26, 19 and 11 times of MV (ET 1). Conclusions: ET 1 may play an important role in the initiation and process of labour and the regulation of blood pressure.