Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression,and suicides |
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Authors: | TJ Crow AJ Cross SJ Cooper JFW Deakin IN Ferrier JA Johnson MH Joseph F Owen M Poulter R Lofthouse JAN Corsellis DR Chambers G Blessed EK Perry RH Perry BE Tomlinson |
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Institution: | 1. Division of Psychiatry, Clinical Research Centre, Northwick Park Hospital, Harrow HA1 3UJ England;2. Runwell Hospital, Wickford, Essex England;3. H.M. Coroner, Inner North London, Camley Street, NW1 OPP England;4. Departments of Neuropathology and Psychiatry, University of Newcastle upon Tyne, England |
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Abstract: | In patients with Alzheimer-type dementia, in addition to the well-known losses of cholinergic neurones, there is evidence of degeneration of the noradrenergic and serotonergic innervation of the cerebral cortex. While noradrenergic and cholinergic receptors are preserved there is a loss of serotonin S1 and S2 receptors, particularly in the temporal lobe. The loss of serotonin S2 receptors may occur at an early stage of the disease and, in temporal and frontal cortex, is correlated with the loss of somatostatin immunoreactivity. In patients dying in hospital with depression, and in individuals committing suicide, there are no consistent changes in monoamine metabolites. Noradrenergic, serotonergic, and other neurotransmitter receptors were found to be unchanged, although there was a moderate decrease in imipramine binding in a small group (n = 6) of subjects with a history of depression, who had committed suicide. |
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Keywords: | Alzheimer dementia depression suicide post-mortem brain monoamine receptors metabolites |
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