| 泽它洗剂中4—氯—3，5—二甲苯酚柱切换HPLC法测定 |
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| 引用本文： | 李世彩,孙山,刘泳. 泽它洗剂中4—氯—3，5—二甲苯酚柱切换HPLC法测定[J]. 中国医药工业杂志, 2001, 32(1): 22-24 |
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| 作者姓名： | 李世彩 孙山 刘泳 |
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| 作者单位： | 山东云门药业有限公司, |
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| 摘 要： | 用柱换HPLC法快速测定泽它洗剂中4－氯－3，5－二甲酚含量。以含量内标羟苯甲酸丙酯的甲醇，超声提取泽它洗剂，离心后取上清液直接进样。预柱为YWGC18（10um），分析柱为Shim-pack CLC-ODS(5um），流动相均为甲醇－水（70：30），检测波长280nm。平均加样回收率为99.84％，RSD＝0.79%.
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| 关 键 词： | 柱切换HPLC 泽它洗剂 4－氯－3 5－二甲苯酚 测定 |
| 文章编号： | 1001-8255(2001)01-0022-03 |
| 修稿时间： | 1999-09-28 |
Determination of4-Chloro-3,5-xylenol in Zetar Lotion by CS-HPLC |
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| LI Shi-cai,Sun Shan,LIU Yong. Determination of4-Chloro-3,5-xylenol in Zetar Lotion by CS-HPLC[J]. , 2001, 32(1): 22-24 |
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| Authors: | LI Shi-cai Sun Shan LIU Yong |
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| Abstract: | 4-Chloro-3,5-xylenol(1) in Zetar lotion was extracted by methanol and determined by column-switching HPLC (CS-HPLC). Propylparaben was used as internal standard. The precolumn was packed with YWG C18 and the Shim-pack CLC-ODS was used as analytical column, with the mobile phase of methanol-water (70∶30). The flow rate was 2.0 ml/min and detection wavelength was 280 nm. The standard curve of 1 was linear over the concentration range of 44.44～131.25 μg/ml. The average recovery was 99.84% with RSD=0.79%. |
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| Keywords: | CS HPLC zetar lotion 4 chloro 3 5 xylenol determination@ |
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