乙型肝炎病毒核苷（酸）类似物耐药研究进展

核苷（酸）类似物耐药问题是慢性乙型肝炎抗病毒治疗中的重要问题之一。随着核苷（酸）类似物耐药研究的不断进展，耐药检测新技术逐渐被研发，对病毒变异的机制了解更加精确且全面。核苷（酸）类似物新的可疑耐药位点不断被提出，但这些位点的临床意义尚待进一步明确。尤其是慢性乙型肝炎患者应用核苷（酸）类似物抗病毒治疗的过程即是病毒与机体相互作用的过程逐渐被认知，在此过程中病毒准种及全基因组序列存在动态演变。核苷（酸）类似物耐药仅为此相互作用过程的表现之一，应将核苷（酸）类似物耐药放在机体免疫与病毒相互作用的整体背景下进行研究。

Progress in hepatitis B virus resistance to nucleos(t)ide analogues

Nucleos(t)ide analogues resistance is still one of the most important questions in management of patients with chronic hepatitis B. New techniques to detecting resistant mutations were developed, showing the resistance more precisely and comprehensively. New possible variants related to nucleos(t)ide analogues resistance were identified, but the clinical significance still need to be verified. The researches on nucleos(t)ide analogues resistance as one of the manifestations in dynamic interaction between HBV and host immunity during nucleos(t)ide analogues therapy were realized. And nucleos(t)ide analogues resistance in the background of virus-host interaction should be understanded.