间充质干细胞治疗胰腺炎的研究进展

目前胰腺炎的临床治疗仍以对症支持治疗为主,具有住院周期长、医疗费用高和高病死率,因此亟需寻找到一种新的治疗策略。间充质干细胞(MSCs)因其高度的自我更新、多向分化潜能、低免疫原性以及免疫调节功能等优势,已成为再生医学中组织或器官修复的理想种子细胞。近年来众多研究发现MSCs移植胰腺炎动物模型后,不但可归巢到损伤区域,而且可通过抗炎、抗凋亡、促血管新生及免疫调节作用等促进胰腺组织的修复,这表明MSCs有望成为治疗胰腺炎的新策略。笔者就MSCs在急、慢性胰腺炎治疗中的最新研究进展作一综述。

Research progress of mesenchymal stem cell therapy for pancreatitis

At present, the clinical treatment of pancreatitis is mainly supportive, with long period of hospitalization, high medical expenses and high mortality. Therefore, it is urgent to find a new treatment strategy. Mesenchymal stem cells (MSCs) are considered to be ideal seed cells for tissue or organ repair in regenerative medicine, due to well-established self-renewal, multi-lineage differentiation potential, low immunogenicity, as well as immunomodulatory properties. In the last few years, several studies have found that MSCs can not only home to the damage area, but also promote the repair of pancreas injury through anti-inflammation, anti-apoptosis, angiogenesis and immune regulation. These studies suggest that MSCs therapy is a promising strategy for the treatment of pancreatitis. Here, the authors address the latest progress in MSCs therapy for acute and chronic pancreatitis.