| 采用扫描电镜-能谱仪比较水飞法、水洗法及干研法对雄黄饮片质量的影响 |
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| 引用本文： | 张慧,高岩,熊慧,薛雪,刘梦楠,刘欢,张颖,李向日.采用扫描电镜-能谱仪比较水飞法、水洗法及干研法对雄黄饮片质量的影响[J].中国实验方剂学杂志,2018,24(11):22-26. |
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| 作者姓名： | 张慧 高岩 熊慧 薛雪 刘梦楠 刘欢 张颖 李向日 |
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| 作者单位： | 北京中医药大学中药学院中药品质评价北京市重点实验室 |
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| 基金项目： | 国家公益性行业科研专项（2015070042） |
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| 摘 要： | 目的:比较雄黄水飞品、水洗品及干研品中二硫化二砷及各元素的含量,以阐明水飞法、水洗法及干研法对雄黄饮片质量的影响,并对雄黄水飞品、水洗品及干研品进行快速鉴别。方法:依据2015年版《中国药典》(一部)雄黄项下规定对3种炮制品进行含量测定;采用扫描电镜-能谱仪对雄黄3种炮制品进行形貌观察,对3种炮制品中的元素种类及含量进行分析。结果:3种炮制品的二硫化二砷含量排序为水飞品水洗品干研品;水飞品及水洗品的形貌相似,而干研品的形貌与其他2种炮制品不同;3种炮制品的氧元素含量排序呈现干研品水洗品水飞品的趋势。结论:采用扫描电镜-能谱仪可以对雄黄水飞品和干研品进行快速鉴别,为鉴别雄黄不同炮制品提供了一定的技术支持。水飞法的除杂减毒效果最好,水飞品质量优于水洗品和干研品,说明水飞法炮制雄黄具有一定的科学依据。
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| 关 键 词： | 雄黄 水飞法 水洗品 干研品 扫描电镜-能谱仪 |
| 收稿时间： | 2017/10/14 0:00:00 |
Comparison of Effect of Water Grinding,Water Washing and Grinding on Quality of Realgar by Scanning Electron Microscopy-energy Dispersive Spectrometer |
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| ZHANG Hui,GAO Yan,XIONG Hui,XUE Xue,LIU Meng-nan,LIU Huan,ZHANG Ying and LI Xiang-ri.Comparison of Effect of Water Grinding,Water Washing and Grinding on Quality of Realgar by Scanning Electron Microscopy-energy Dispersive Spectrometer[J].China Journal of Experimental Traditional Medical Formulae,2018,24(11):22-26. |
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| Authors: | ZHANG Hui GAO Yan XIONG Hui XUE Xue LIU Meng-nan LIU Huan ZHANG Ying and LI Xiang-ri |
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| Institution: | Beijing Key Laboratory of Traditional Chinese Medicine Quality Evaluation, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China,Beijing Key Laboratory of Traditional Chinese Medicine Quality Evaluation, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China,Beijing Key Laboratory of Traditional Chinese Medicine Quality Evaluation, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China,Beijing Key Laboratory of Traditional Chinese Medicine Quality Evaluation, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China,Beijing Key Laboratory of Traditional Chinese Medicine Quality Evaluation, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China,Beijing Key Laboratory of Traditional Chinese Medicine Quality Evaluation, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China,Beijing Key Laboratory of Traditional Chinese Medicine Quality Evaluation, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China and Beijing Key Laboratory of Traditional Chinese Medicine Quality Evaluation, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China |
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| Abstract: | Objective: To explain the effect of water grinding,water washing and grinding on the quality of Realgar by comparing the contents of As2S2 and elements in different processed products.At the same time,to identify water grinding products,water washing products and grinding products rapidly. Method: To determine the content of As2S2 in different processed products of Realgar by the method in the 2015 edition of Chinese Pharmacopoeia.Scanning electron microscopy-energy dispersive spectrometer (SEM-EDS) was used to observe the surface morphology of different processed products and determine the contents of elements in different processed products. Result: The content of As2S2 in different processed products ranked as water grinding products > water washing products > grinding products.The surface morphology of water grinding products was similar to the surface morphology of water washing products,but the surface morphology of grinding products was different from theirs.The content of oxygen in different processed products showed the trend of grinding products > water washing products > water grinding products. Conclusion: It can be distinguished between water grinding products and grinding products by SEM-EDS,it provides a certain technical support for the identification of different processed products of Realgar.The effect of water grinding on removing impurities and reducing the toxicity is best,quality of water grinding products is better than the quality of water washing products and grinding products,which shows that water grinding for Realgar has scientific basis. |
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| Keywords: | Realgar water grinding water washing product grinding product scanning electron microscopy-energy dispersive spectrometer |
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