大隐静脉源性血管平滑肌细胞表型转化的研究进展

血管平滑肌细胞(VSMCs)表型转化是血管重塑的细胞学基础。收缩表型和合成表型VSMCs反映不同的功能,且两者之间可相互转化。笔者就大隐静脉源性VSMCs表型转化的概念及特点、表型标记物、细胞增殖和迁移,以及基质金属蛋白酶及其抑制物、细胞凋亡、表观遗传学与其表型转化的关系等研究进展进行归纳叙述,旨在为寻找防治静脉曲张相关的药物作用靶点提供理论基础。

Research progress in phenotypic transformation of vascular smooth muscle cells from great saphenous vein

Phenotypic transformation of the vascular smooth muscle cells (VSMCs) is considered the cytological basis of vascular remodeling. VSMCs with contractile phenotype and synthesis phenotype exhibit different functions, and they can transform to each other reciprocally. Here, the authors review and extract the research progress in terms of the concept and characteristics of phenotypic transformation, phenotype markers, and proliferation and migration of the VSMCs derived from the great saphenous vein, as well as the relation of the matrix metalloproteinases and their inhibitors, apoptosis, and epigenetic factors with their phenotypic transformation, so as to provide a theoretical foundation for screening the drug targets associated with prevention and treatment of varicose veins.