中医药逆转胰腺癌耐药性的研究进展

胰腺癌作为恶性程度极高的消化道肿瘤,化疗是临床治疗主要手段之一,但是由于肿瘤细胞多药耐药现象,使胰腺癌化疗疗效不够理想,而其机制尚未完全明确。为了解决这一难题,科学家们致力于研制出新型的治疗手段和解决耐药问题,随着科技的发展,越来越多的科技手段有望为治疗胰腺癌提供全新的治疗方法,而研制成功到运用于临床仍需要一定的时间,不能解决现阶段胰腺癌治疗难题,这就使得解决胰腺癌临床治疗耐药问题在现阶段十分必要。随着中国的国际影响力不断提高,中国传统文化也越来受到人类的关注,近年来,国家对中医文化的重视度和推动力也大大提高,中医药作为中国人同疾病斗争的宝贵遗产,治疗肿瘤历史悠久,毒副作用相对较小,苦痛少,不会给患者家庭带来过重的经济负担而更容易被患者接受。近年来已有文献报道,多味中医药抑制肿瘤细胞增殖具有显著作用,甚至能逆转肿瘤细胞耐药,临床研究也观察发现中医药对肿瘤的治疗呈现出较好的治疗效果。目前为止,文献对近几年来中药逆转胰腺癌耐药的总结性研究较少,不能体现出科学家在相关领域所作出的研究现状。本文对胰腺癌耐药蛋白异常表达等方面的耐药机制,与汉防己甲素、大黄素、虾青素、姜黄素等中医药逆转肿瘤耐药的研究进展进行综述。

Effect of Traditional Chinese Medicine in Reversal of Pancreatic Cancer Drug Resistance

Pancreatic cancer is a malignant tumor of the digestive tract. However, its mechanism is not fully understood because of the multidrug resistance of tumor cells. In order to solve the drug resistance problem, scientists are committed to developing new chemotherapeutic methods. With the development of science and technology, more and more scientific and technological means are expected to provide brand-new treatment methods for treating pancreatic cancer. However, it still takes time from the successful development to clinical application, and the current problem of pancreatic cancer treatment still cannot be solved. Therefore, it is necessary to solve the drug resistance in the clinical treatment of pancreatic cancer at this stage. With the continuous improvement of China''s international influence, the traditional Chinese culture has also drawn more and more attention. It is worth mentioning that in recent years, the government has attached more importance to the culture of traditional Chinese medicine and made increasing efforts in driving it. Chinese herbal medicine has been a valuable legacy for Chinese people to struggle with diseases, with a long history and low toxic and side effects, and more affordable by patients. In recent years, it has been reported in the literatures that Chinese herbal medicine compounds have a significant effect in inhibiting the proliferation of tumor cells and can even reverse the drug resistance of tumor cells. Clinical studies have also found that Chinese herbal medicine has a better therapeutic effect on tumor treatment. So far, the literatures on the effect of traditional Chinese medicines(TCM) in reversing the drug resistance of pancreatic cancer in recent years cannot reflect the advance of studies in the field. In this paper, the mechanism of drug resistance in the abnormal expression of pancreatic cancer drug resistance, and the effects of anti-tetrandrine, emodin, astaxanthin, curcumin and other TCM in reversing the progress of tumor drug resistance were reviewed.