| 蜘蛛香总缬草三酯自微乳的制备及质量评价 |
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| 引用本文： | 刘开萍,程盛勇,郁林娜,罗喜荣,杨军,刘兴赋,尹航.蜘蛛香总缬草三酯自微乳的制备及质量评价[J].中国实验方剂学杂志,2018,24(11):16-21. |
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| 作者姓名： | 刘开萍 程盛勇 郁林娜 罗喜荣 杨军 刘兴赋 尹航 |
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| 作者单位： | 贵州医科大学药学院;中国科学院地球化学研究所 |
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| 基金项目： | 贵州省社发攻关项目（黔科合SY字[2015]3032号）；贵州省中药现代化专项项目（黔科合ZY字[2012]3010号）；贵州省联合基金项目（黔科合LH字[2014]7091号） |
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| 摘 要： | 目的:制备蜘蛛香总缬草三酯自微乳并对其质量进行评价,为该有效部位的后续研究与开发提供参考。方法:通过溶解度考察、配伍试验和三元相图法优选处方;以油相、乳化剂及助乳化剂比例为考察因素,粒径、自乳化时间及载药量为评价指标,采用单纯形质心混料设计优化蜘蛛香总缬草三酯自微乳处方并对其药剂学性质进行评价。结果:蜘蛛香总缬草三酯自微乳最佳处方为油酸乙酯-(15-羟基硬脂酸聚乙二醇酯)-二乙二醇单乙基醚(10∶61∶29);平均粒径38.8 nm,自乳化时间0.57 min,载药量131.23 mg·g-1,5 min累积溶出度达94.99%;高温及光照会影响该制剂的稳定性,应低温避光保存。结论:蜘蛛香总缬草三酯自微乳制备工艺简单,可显著改善蜘蛛香总缬草三酯的水溶性和溶出度,有望提高其口服生物利用度。
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| 关 键 词： | 蜘蛛香 总缬草三酯 抗抑郁 镇静催眠 自微乳 三元相图 单纯形质心混料设计 |
| 收稿时间： | 2017/12/1 0:00:00 |
Preparation and Quality Evaluation of Self-microemulsion of Total Valepotriates in Valerianae Jatamansi Rhizoma et Radix |
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| LIU Kai-ping,CHENG Sheng-yong,YU Lin-n,LUO Xi-rong,YANG Jun,LIU Xing-fu and YIN Hang.Preparation and Quality Evaluation of Self-microemulsion of Total Valepotriates in Valerianae Jatamansi Rhizoma et Radix[J].China Journal of Experimental Traditional Medical Formulae,2018,24(11):16-21. |
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| Authors: | LIU Kai-ping CHENG Sheng-yong YU Lin-n LUO Xi-rong YANG Jun LIU Xing-fu and YIN Hang |
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| Institution: | School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China,School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China,School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China,School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China,Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China,School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China |
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| Abstract: | |
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| Keywords: | Valerianae Jatamansi Rhizoma et Radix total valepotriates antidepressant sedative-hypnotic self-microemulsion ternary phase diagram simplex centroid mixture design |
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