| Protective effect of albumin on lung injury in traumatic/hemorrhagic shock in rats |
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| 作者姓名： | 丁晨彦 陈作兵 郑树森 高原 张匀 赵雪红 倪玲美 |
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| 作者单位： | The Department of Emergency Surgery，First AffiliatedHospital，College of Medicine，Zhejiang University，Hangzhou310003，China，The Department of Emergency Surgery，First AffiliatedHospital，College of Medicine，Zhejiang University，Hangzhou310003，China，The Department of Emergency Surgery，First AffiliatedHospital，College of Medicine，Zhejiang University，Hangzhou310003，China，The Department of Emergency Surgery，First AffiliatedHospital，College of Medicine，Zhejiang University，Hangzhou310003，China，The Department of Emergency Surgery，First AffiliatedHospital，College of Medicine，Zhejiang University，Hangzhou310003，China，The Department of Emergency Surgery，First AffiliatedHospital，College of Medicine，Zhejiang University，Hangzhou310003，China，The Department of Emergency Surgery，First AffiliatedHospital，College of Medicine，Zhejiang University，Hangzhou310003，China |
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| 基金项目： | ThisstudywassupportedbytheResearchFoundationofChineseMedicineManagementBureau,ZhejiangProvince(No.2004C071) |
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| 摘 要： | Ctodrlealbouiamdtea v.e1r rsAeumlsth acoirnuysgshta lamloaid ncy oren sstturuosdvcieietrassti iaholanv eisnu abtdhjdeerc aetscsu eotdefthat the relative benefits of albumin resuscitation,noconsensus has been reached by now.2Recently,theimmunomodulatory ef…
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Protective effect of albumin on lung injury in traumatic/hemorrhagic shock in rats |
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| DING Chen-yan,CHEN Zuo-bing,ZHENG Shu-sen,GAO Yuan,ZHANG Yun,ZHAO Xue-hong,NI Ling-mei.Protective effect of albumin on lung injury in traumatic/hemorrhagic shock in rats[J].Chinese Journal of Traumatology(English Edition),2005,8(5). |
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| Authors: | DING Chen-yan CHEN Zuo-bing ZHENG Shu-sen GAO Yuan ZHANG Yun ZHAO Xue-hong NI Ling-mei |
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| Abstract: | Objective: To determine the effect of albumin administration on lung injury in traumatic/hemorrhagic shock (T/HS) in rats. Methods: Forty-eight adult Sprague-Dawley rats were divided into three groups randomly (n=16 in each group): Group A, Group B, Group C. In Group A, rats underwent laparotomy without shock. In Group B, rats undergoing T/HS were resuscitated with their blood plus lactated Ringer's (twice the volume of shed blood). In Group C, rats undergoing T/HS were resuscitated with their shed blood plus additional 3 ml of 5% human albumin. The expression of polymorphonuclear neutrophils CD18/CD11b in jugular vein blood was evaluated. The main lung injury indexes (the activity of myeloperoxidase and lung injury score) were measured. Results: Significant differences of the expression of CD18/11b and the severity degree of lung injury were found between the three groups. (P< 0.05). The expression of CD18/CD11b and the main lung injury indexes in Group B and Goup C incresed significantly compared with those in Group A (P< 0.05).At the same time, the expression of CD18/CD11b and the main lung injury indexes in Group C decreased dramatically, compared with those in Group B (P< 0.05). Conclusions: The infusion of albumin during resuscitation period can protect lungs from injury and decrease the expression of CD18/CD11b in T/HS rats. |
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| Keywords: | Albumins Respiratory distress syndrome adult Traumatic/hemorrhagic shock |
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