| 血管内皮细胞生长因子受体酪氨酸激酶抑制剂的研究进展 |
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| 引用本文： | 钟毅,李志裕,尤启冬. 血管内皮细胞生长因子受体酪氨酸激酶抑制剂的研究进展[J]. 中国新药杂志, 2006, 15(3): 181-185 |
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| 作者姓名： | 钟毅 李志裕 尤启冬 |
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| 作者单位： | 中国药科大学药物化学教研室,南京,210009 |
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| 基金项目： | 中国药科大学校科研和教改项目 |
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| 摘 要： | 血管内皮细胞生长因子受体（VEGFR）家族的受体酪氨酸激酶与多种恶性肿瘤的发生、发展及预后等密切相关。近年来，许多以此为靶点的新的抗肿瘤药物和治疗方法陆续被开发。综述了作用于VEGFR的酪氨酸激酶抑制剂bevacizumab，PTK787，BAY43-9006，SU11248和ZD6474的研究进展。
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| 关 键 词： | 血管内皮细胞生长因子受体 受体酪氨酸激酶 肿瘤 |
| 文章编号： | 1003-3734（2006）03-0180-05 |
| 收稿时间： | 2004-11-04 |
| 修稿时间： | 2004-11-04 |
Investigations in vascular endothelial growth factor receptor family tyrosine kinase inhibitor |
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| ZHONG Yi,LI Zhi-yu,YOU Qi-dong. Investigations in vascular endothelial growth factor receptor family tyrosine kinase inhibitor[J]. Chinese Journal of New Drugs, 2006, 15(3): 181-185 |
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| Authors: | ZHONG Yi LI Zhi-yu YOU Qi-dong |
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| Affiliation: | Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | The tyrosine kinase levels of vascular endothelial growth factor receptor (VEGFR) fami- ly are closely associated with incidence,metastasis and prognosis of many kinds of malignant tumor.A few of the VEGFR-targeted antineoplastic therapies have been impressively developed in passing years.This ar- ticle briefly introduced VEGFR status and summarized the investigations of VEGFR family tyrosine kinase inhibitors,such as bevacizumab,PTK787,BAY 43-9006,SU11248 and ZD6474. |
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| Keywords: | vascular endothelial growth factor receptor receptor tyrosine kinase tumor |
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