| 抗癌药达沙替尼的热稳定性与晶型研究 |
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| 引用本文： | Zhao YN,Chen XQ,Zhu K,Li G. 抗癌药达沙替尼的热稳定性与晶型研究[J]. 药学学报, 2011, 46(9): 1104-1107 |
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| 作者姓名： | Zhao YN Chen XQ Zhu K Li G |
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| 作者单位： | 南京师范大学分析测试中心; |
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| 基金项目： | 江苏省自然科学基金资助项目(BK2001111); 江苏省生物医药材料测试服务平台资助项目(BM20007132) |
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| 摘 要： | 本文对药物达沙替尼的热稳定性和晶型进行分析与研究。通过差示扫描量热仪(DSC)和热重分析仪(TGA)分析达沙替尼的热稳定性;通过X射线粉末衍射仪(XRD)及其原位高温附件(in situ high temperature)测定达沙替尼试样的多晶型结构及相转变。结果表明,达沙替尼存在两种晶型(分子中分别含1个结晶水和1.5个结晶水),在加热过程中两种晶型都会发生结构变化,失去结晶水后,最终变为相同的晶体结构,其熔点分别为285.68℃和285.50℃。
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| 关 键 词： | 达沙替尼 热分析 X线粉末衍射 多晶型 |
Thermostability and crystal structure of anticancer drug dasatinib |
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| Zhao Ya-nan,Chen Xiao-qing,Zhu Kan,Li Gang. Thermostability and crystal structure of anticancer drug dasatinib[J]. Acta pharmaceutica Sinica, 2011, 46(9): 1104-1107 |
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| Authors: | Zhao Ya-nan Chen Xiao-qing Zhu Kan Li Gang |
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| Affiliation: | ZHAO Ya-nan,CHEN Xiao-qing,ZHU Kan,LI Gang (Test & Analysis Center,Nanjing Normal University,Nanjing 210046,China) |
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| Abstract: | This article studies the thermostability and the crystal structure of a new anticancer drug dasatinib.The thermostability of dasatinib was analyzed using the differential scanning calorimeter(DSC) and thermo gravimetric analyzer(TGA),and the structural characteristics of polymorphism and crystalline transformation was determined using the X-ray powder diffractometry(XRD) with in-situ high temperature accessories.The results showed that dasatinib has at least two different crystal forms.The form-I has one cr... |
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| Keywords: | dasatinib thermal analysis X-ray powder diffraction polymorphism |
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