七价肺炎球菌结合疫苗的安全性监测评价

目的]评价七价肺炎球菌结合疫苗的安全性。方法]2010年10～11月对215名到济南市中心医院预防接种门诊接种七价肺炎球菌结合疫苗者,年龄为3个月至3岁的婴幼儿进行七价肺炎球菌结合疫苗(沛儿prevenar)接种后不良反应的临床观察,分别于接种疫苗后30min和12、24、48、72h观察不良反应,直至不良反应消失。结果]共观察215名婴幼儿,19人(占8.84%)发生不良反应,共23例次,不良反应发生率为8.84%。3个月至1岁11个月组接种112人,发生不良反应的10人,不良反应发生率8.93%;2～3岁组接种103人,发生不良反应的9人,不良反应发生率为8.74%,二者差异无统计学意义(P>0.05)。局部反应为14例次,全身反应为9例次,均于对症治疗3日内缓解、消失。结论]临床观察证明接种七价肺炎球菌结合疫苗有较好的安全性。

Surveillance and Safety Evaluation of Pneumococcal 7-Valent Conjugate Vaccine

Objective]To evaluate safety of pneumococcal 7-valent conjugate vaccine.Methods]Clinical observation of adverse reaction was carried out for 215 children aged from 3 months to 3 years who were given pneumococcal 7-valent conjugate vaccine in immunization service department of the hospital from October to November 2010.The observation began 30 min,24 h,48 h and 72 h later after vaccination until adverse reaction disappeared.Results]Of the 215 children,19 of them had adverse reactions,accounting for 8.84%(...