| 增塑剂及膜材比例对Eudragit L100/S100游离膜机械性能和透湿性的影响 |
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| 引用本文： | Zhang GS,Feng CH,Jiang W,Hu PY,Deng P,Zhang Y,Luo XJ. 增塑剂及膜材比例对Eudragit L100/S100游离膜机械性能和透湿性的影响[J]. 药学学报, 2011, 46(9): 1144-1149 |
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| 作者姓名： | Zhang GS Feng CH Jiang W Hu PY Deng P Zhang Y Luo XJ |
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| 作者单位： | 中药固体制剂制造技术国家工程研究中心;江西中医学院;南昌航空大学医院; |
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| 基金项目： | 国家自然科学基金资助项目(C0302050207) |
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| 摘 要： | 采用平面铸膜法制备对pH敏感、可用于结肠定位的Eudragit L100/S100游离膜,并考察成膜湿度、增塑剂的种类与用量及膜材的比例对游离膜的影响。以膜的透湿性、机械性能为指标设计正交实验,优选出最佳的成膜处方,并研究其相关特性。结果表明,以柠檬酸三乙酯为增塑剂且含量为30%时,膜的机械性能和成膜性最好;膜材比例变化对游离膜的机械性能和透湿性影响不大。通过调整增塑剂的种类、用量及Eudragit L100/S100配比,可以制得符合结肠定位释放要求的游离膜。
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| 关 键 词： | Eudragit L100/S100 正交实验 透湿性 机械性质 |
The mechanical properties and moisture permeability of eudragit L100/S100 free films affected by plasticizers and membrane materials ratio |
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| Zhang Guo-song,Feng Chuan-hua,Jiang Wei,Hu Peng-yi,Deng Ping,Zhang Yao,Luo Xiao-jian. The mechanical properties and moisture permeability of eudragit L100/S100 free films affected by plasticizers and membrane materials ratio[J]. Acta pharmaceutica Sinica, 2011, 46(9): 1144-1149 |
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| Authors: | Zhang Guo-song Feng Chuan-hua Jiang Wei Hu Peng-yi Deng Ping Zhang Yao Luo Xiao-jian |
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| Affiliation: | ZHANG Guo-song 1,FENG Chuan-hua 2,JIANG Wei 2,HU Peng-yi 2,DENG Ping 3,ZHANG Yao 1,LUO Xiao-jian 1,2 (1.The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine,Nanchang 330006,China,2.Jiangxi College of Traditional Chinese Medicine,Nanchang 330004,3.The Hospital of Nanchang Aeronautical University,China) |
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| Abstract: | The free membrane of Eudragit L100/S100 which is pH-sensitive,colon-specific was prepared by plane casting films.The film humidity,species and amount of plasticizers,the ratio of membrane material was investigated.The rate of membrane permeability and mechanical properties were used as indicators of orthogonal experiment,and its related properties were studied.The results show that the mechanical properties of the membrane and phragmoid capacity are the best when 30% TEC was used as plasticizer;the ratio of... |
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| Keywords: | Eudragit L100/S100 orthogonal moisture permeability mechanical property |
| 本文献已被 CNKI PubMed 等数据库收录！ |
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