| 二萜合酶的研究进展 |
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| 引用本文： | He YF,Gao W,Liu TS,Li WY,Huang LQ. 二萜合酶的研究进展[J]. 药学学报, 2011, 46(9): 1019-1025 |
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| 作者姓名： | He YF Gao W Liu TS Li WY Huang LQ |
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| 作者单位： | 中国中医科学院中药研究所;湖南中医药大学药学院;首都医科大学中医药学院; |
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| 基金项目： | 国家自然科学基金资助项目(81072990),国家自然科学基金青年科学基金资助项目(30901965); 北京市自然科学基金资助项目(5102009) |
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| 摘 要： | 植物二萜类化合物广泛存在于自然界中,是一类重要的天然化合物。随着一些具有重要经济价值的二萜不断被发现,其生物合成中的二萜合酶也倍受关注。二萜合酶催化活性的多样性决定了终产物(二萜化合物)的丰富性。本文重点探讨了近年来二萜生物合成途径和二萜合酶的类型、克隆、催化机制及其合成生物学应用等研究进展。
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| 关 键 词： | 二萜合酶 生物合成途径 克隆 催化机制 合成生物学 |
Research advances of diterpene synthase |
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| He Yun-fei,Gao Wei,Liu Ta-si,Li Wen-yuan,Huang Lu-qi. Research advances of diterpene synthase[J]. Acta pharmaceutica Sinica, 2011, 46(9): 1019-1025 |
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| Authors: | He Yun-fei Gao Wei Liu Ta-si Li Wen-yuan Huang Lu-qi |
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| Affiliation: | HE Yun-fei 1,2,GAO Wei 3,LIU Ta-si 2,LI Wen-yuan 1,HUANG Lu-qi 1 (1.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China,2.School of Chinese Materia Medica,Hunan University of Traditional Chinese Medicine,Changsha 410208,3.School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China) |
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| Abstract: | Diterpenes, an important class of natural compounds, are widely distributed in nature. As the valuable diterpenoids continue to be found, diterpene synthase in the course of diterpene synthesis get as much attention as possible. The multiformity of end-product-diterpenoids were also due to the diversity of diterpene synthase. This paper focuses on the advances in recent biosynthesis pathway of diterpene and types, cloning, catalytic mechanism, synthetic biology application. |
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| Keywords: | diterpene synthase biosynthesis pathway cloning catalytic mechanism synthetic biology |
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