KIR基因多态性与HBV感染及干扰素疗效的相关性研究

[目的]探讨KIR基因多态性与乙型肝炎病毒(HBV)感染及机体对干扰素抗HBV治疗应答差异的相关性。[方法]于2010年以2005~2008年青岛市传染病医院就诊的乙肝患者160例为病例组(HBV急性自限性感染者60例为急乙肝组、慢性HBV持续性感染者100例为慢乙肝组),从中国造血干细胞志愿捐献者库青岛分库中随机选择健康捐献者100名为对照组,对照组间及其与病例组间均无亲缘关系。慢乙肝组中48例为干扰素治疗完全应答者(应答组),52例为干扰素治疗低应答者或不应答者(无应答组),分别进行KIR基因分型检测并比较其分布情况。[结果]KIR2DS4*001-002的阳性率,慢乙肝组为87.00%,急乙肝组为73.33%,对照组为72.00%(P<0.05或<0.01)。慢乙肝组中,KIR 2DS4003-007的阳性率干扰素治疗应答组与无应答组分别为18.75%、55.77%(P<0.01);3DP*1001/002/004阳性率应答组与非应答组分别为14.58%、0.00%(P<0.01);2DL5B*002/004/007阳性率应答组与无应答组分别为10.42%、0.00%(P<0.05)。[结论]KIR 2DS4*001-002可能与HBV感染慢性化有关。KIR 2DS4*003-007可能与干扰素对HBV的无应答有关,3DP*1001/002/004和2DL5B*002/004/007基因可能有助于慢性乙型肝炎患者干扰素治疗的应答。

Study on the Relationship between the Polymorphism of KIR Gene and the Susceptibility to HBV Infection and the Treatment Response of Interferon

[Objective]To study the association between the polymorphism of killer cell immunoglobulin-like receptors(KIR) gene and the prognosis of HBV infection and the treatment response of interferon.[Methods]160 hepatitis B patients were enrolled from Qingdao hospital for infectious diseases during 2005-2008 as the patient group,including 60 cases of patients recovered from acute HBV infection as acute hepatitis B group(AHB),100 cases of HBV chronic infection as chronic hepatitis B group(CHB).To select randomly 10...