谷氨酰胺对早产儿胃肠道屏障及免疫功能的影响

谷氨酰胺(Gln)一般被认为是非必需氨基酸,但在应激状态下,因机体对Gln的需要超过其合成能力,它可能是必需的。另外,Gln还是一种免疫营养素。补充Gln可以防止细菌移位,维持肠黏膜屏障,对胃肠道免疫功能有调节作用。早产儿尤其是极低出生体质量儿补充Gln可以减少院内感染的发生,提高其对胃肠道喂养的耐受性,缩短肠外营养的时间,减少住院时间等。

The Effect of Glutamine on the Gastrointestinal Tract and Immune Function in Preterm Infants

Glutamine(Gln) is generally considered a nonessential amino acid.It is a conditionally essential amino acid when the need of the Gln excesses the synthesis of it in the stress.In addition,Gln is an immune nutrient.It can prevent bacterial displacement,maintain the intestinal barrier,plays a part in the immune function of the gastrointestinal tract.To preterm infants,especially very low birth weight,it can reduce the incidence of nosocomial infections,improve the tolerance of enteral nutrition,shorten the ti...