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Partitioning heritability analyses unveil the genetic architecture of human brain multidimensional functional connectivity patterns
Authors:Junjiao Feng  Chunhui Chen  Ying Cai  Zhifang Ye  Kanyin Feng  Jing Liu  Liang Zhang  Qinghao Yang  Anqi Li  Jintao Sheng  Bi Zhu  Zhaoxia Yu  Chuansheng Chen  Qi Dong  Gui Xue
Abstract:Resting‐state functional connectivity profiles have been increasingly shown to be important endophenotypes that are tightly linked to human cognitive functions and psychiatric diseases, yet the genetic architecture of this multidimensional trait is barely understood. Using a unique sample of 1,704 unrelated, young and healthy Chinese Han individuals, we revealed a significant heritability of functional connectivity patterns in the whole brain and several subnetworks. We further proposed a partitioned heritability analysis for multidimensional functional connectivity patterns, which revealed the common and unique enrichment patterns of the genetic contributions to brain connectivity patterns for several gene sets linked to brain functions, including the genes expressed preferentially in the central nervous system and those associated with intelligence, educational attainment, attention‐deficit/hyperactivity disorder, and schizophrenia. These results for the first time reveal the genetic architecture of multidimensional brain connectivity patterns across different networks and advance our understanding of the complex relationship between gene sets, neural networks, and behaviors.
Keywords:cognitive functions  multidimensional functional connectivity patterns  partitioned heritability  psychiatric diseases  SNP‐based heritability
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