吸烟者静息态fMRI脑功能连接研究

目的 采用静息态fMRI分数低频振幅技术（fALFF）及功能连接方法分析吸烟者脑功能活动。方法 收集53名吸烟者（吸烟组）和53名不吸烟者（对照组）的静息态fMRI资料，并将吸烟组分为少量吸烟亚组与大量吸烟亚组、轻度成瘾亚组与重度成瘾亚组，计算受检者fALFF值，观察2组及不同亚组间fALFF值、全脑功能连接差异。结果 与对照组相比，吸烟组左侧边缘叶等脑区fALFF值增加，右侧颞上回等脑区fALFF值下降；与少量吸烟亚组相比，大量吸烟亚组右侧颞上回等脑区fALFF值升高，双侧边缘叶等脑区fALFF值下降；与轻度成瘾亚组相比，重度成瘾亚组双侧额中回等脑区fALFF值增加，左侧边缘叶等脑区fALFF值下降。吸烟组较对照组可见多发功能连接增强和减低的脑区。结论 吸烟者与成瘾相关脑区活动增强、情绪控制脑区活动减弱，且部分脑区活动改变与吸烟量及烟瘾程度有关。

Study of resting-state fMRI on brain function connection in smokers

Objective To analyze the function connection of the brain in smokers with resting-state fMRI. Methods Resting-state fMRI data of 53 smokers (smoking group) and 53 non-smokers (control group) were observed. The subjects in smoking group were divided into small or large amount smoking subgroup, as well as mild or severe addiction subgroup. The fractional amplitude of low-frequency fluctuation (fALFF) values of all subjects were calculated, and the differences of fALFF values and whole brain functional connectivity were observed. Results Compared with control group, fALFF significantly increased in the left limbic lobe, and decreased in the right superior temporal gyrus in smoking group. Compared to small amount smoking subgroup, fALFF significantly increased in the right superior temporal gyrus, and decreased in the bilateral limbic lobe in large amount smoking subgroup. Compared with mild addiction subgroup, fALFF significantly increased in the bilateral middle frontal gyrus, and decreased in the left limbic lobe in severe addiction subgroup. There are many increased and decreased functional connectivity brain areas in smoking group compared with control group. Conclusion There are many activity changes in addiction related brain areas and less in emotion control areas in smokers, and some brain areas activation changes are related to smoking amount and addiction level.