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| 引用本文： | ??????,?????,????,????,???÷,?????.??????????????θ??????????????????????о?[J].中国实用儿科杂志,2010,25(6):460. |
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| 作者姓名： | ?????? ????? ???? ???? ???÷ ????? |
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| 作者单位： | ?????ж???? ???????????????????????????????? ??710002 |
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| 摘 要： |
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| 关 键 词： | ?????????? θ????????????? |
Study of the GRPR polymorphisms in ADHD children. |
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| CHEN Yan-Ni,HUANG Yan-Xia,ZHANG ??Jie,SHAO Dong-Dong,ZUO Xue-Mei,HE ??Chi.Study of the GRPR polymorphisms in ADHD children.[J].Chinese Journal of Practical Pediatrics,2010,25(6):460. |
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| Authors: | CHEN Yan-Ni HUANG Yan-Xia ZHANG ??Jie SHAO Dong-Dong ZUO Xue-Mei HE ??Chi |
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| Abstract: | ??Abstract??Objective??To study the GRPR polymorphisms in ADHD children and analyze the sequence of the second exon of GRPR. Methods??The DNA was taken from the periphery blood. The PCR of the second exon of 120 children with ADHD and 126 normal children was sequenced. We used Chi-square test to know difference of genotype and haplotype between ADHD and normal control group?? and among inattention?? hyperactivity and impulsivity compound group. Result??There were TT?? CC and TC polymorphisms in the second exon of GRPR in 661 and 450 sits. There was no difference between ADHD and normal control group??χ2 = 0.30??0.52??1.34??0.30??all P > 0.05??. There was no difference among inattention?? hyperactivity and impulsivity compound group??χ2 = 0.37??0.49??0.63??all P > 0.05??. Conclusion??The research has not proved the relationship between ADHD and the second exon of GRPR. |
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| Keywords: | attention deficit hyperactivity disorder??ADHD?? gastrin-releasing peptide receptor??GRPR?? polymorphism |
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