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Study on the genotype of Mycobacterium tuberculosis isolates and its drug resistance.

??Abstract??Objective??To explore the characteristics on molecular epidemiology of Mycobacterium tuberculosis isolates in chilidren and to analyse the relationship between drug resistance and genotype. Methods??Totally 150 M.tuberculosis isolated strains were collected from Children's Hospital of Chongqing Medical University and typed by MIRU genotyping.The relationship between genetic type and drug resistance was explored. Results??The 150 strains were divided into 89 distinct MIRU patterns’ and 65 isolates of them were unique. Totally 85 strains were grouped into 24 different MIRU clusters. The MIRU genotype of the largest cluster was 223325173533. Drug resistant M. tuberculosis wasn’t associated with cluster type. Conclusion??223325173533 genotype was perhaps the main epidemic strains for children in Chongqing. Drug-resistance might have no relationship with the clustering genotype.