电刺激诱发肢体持续麻木感静息态fMRI研究

目的 采用静息态fMRI (rs-fMRI)比率低频振幅 (fALFF)检测电刺激诱发肢体持续麻木感脑功能变化情况,探讨持续性麻木脑机制。方法 对21名健康成年志愿者有无电刺激分别行静息态fMRI扫描,并要求被试对同一脉冲电刺激行麻木感强度评分。通过fALFF算法对有无电刺激脑fALFF值进行分析,并获得两者显著差异脑区,进一步将给予电刺激脑fALFF与个体麻木感强度评分作相关分析。结果 与无电刺激比较,给予电刺激fALFF值显著增强脑区：额叶内侧皮质、前扣带回、两侧颞中回、两侧颞下回和右侧颞极；显著减弱的脑区：楔前叶/后扣带回、右侧小脑。给予电刺激脑fALFF与个体麻木感评分显著正相关的脑区有楔前叶/后扣带回和左侧颞中回；显著负相关脑区有右侧额极和左侧颞下回。结论 电刺诱发肢体持续麻木感涉及感觉运动、情绪和认知功能相关脑区,且与默认网络脑区密切相关,楔前叶 /后扣带回、颞叶及额叶部分脑区与个体麻木感差异性相关,本研究为探讨麻木感相关脑机制提供新的范式。

Study of resting-state fMRI in limb persistent numbness induced by electrical stimulation

Objective To investigate brain function changes in limb persistent numbness induced by electrical stimulation by using fractional amplitude of low frequency fluctuation of resting-state fMRI (rs-fMRI), and to discuss the brain mechanism of persistent numbness. Methods totally 21 healthy adult volunteers with and without numb stimulation underwent resting-state fMRI scans, and the volunteers were asked to rate the nubmness intensity of the same electrical stimulation. Using fLAFF algorithm to analyze the fALFF date of the brain with and without stimulation and acquire the significantly brain regions , and correlation analysis was performed between the stimulation brain fALFF date with the individual numbness intensity score. Results compared with none nubmbness stimulation, the brain regions with fALFF increased in nubmbness stimulation are medial frontal cortex, anterior cingulate cortex, bilateral medial temporal gyrus, bilateral inferior temporal gyrus and right temporal pole; brain regions with fALFF weakened are precuneus / posterior cingulate cortex and right cerebellum. The brain regions positively correlated with individual numbness scores have anterior precuneus / posterior cingulate cortex and left medial temporal gyrus, and the negatively associated brain region have right frontal pole and left inferior temporal gyrus. Conclusion The limb persistent numbness involves brain regions of sensorimotor, emotional and cognitive functions.,and is related to default mode network . The precuneus / posterior cingulate cortex, temporal lobe and frontal lobe are closely related to individual numbness. This study provides a new paradigm to explore the brain mechanisms of numbness.