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The electrophysiology and clinical characteristics of the children with Guillain-Barré syndrome.

??Abstract??Objective??To study the epidemiology??clinical and electrophysiological characteristics of the children with Guillain-Barré syndrome. Methods??Retrospectively analyze the electrophysiological and clinical data of 77 children wtih GBS in our hospital. Results??According to clinical and electrophysiologic findings??32 patients manifested acute inflammatory demyelinating polyradiculoneuropathy??AIDP???? 34 had acute motor axonal neuropathy??AMAN????4 had acute motor and sensory axonal neuropathy??ASMAN???? 4 were inexcitable?? 2 were unclassified and 1 had Miller-Fisher syndrome. The 77 patients included 53 boys and 25 girls.There were 27 boys and 5 girls in AIDP group and 18 boys and 16 girls in AMAN group. The AMAN group wer clearly seasonal ??June 4 to August 28?? .The mean time from the onset of illness to nadir was 7.09±3.17 days in the AIDP group and 4.94±1.59 days in the AMAN group. The mean disability score at nadir by the Hughes scale of 12 cases in AIDP group and 9 cases in AMAN group was ≤3??and 20 cases in AIDP group and 25 cases in AMAN group was ≥4.The number of cases in the respiratory muscle paralysis?? cranial nerve palsy and autonomic symptoms in the AMAN was more than in the AIDP group??but there was no statistical significance. In the sensory nerve involvement?? the AIDP was obviously more severe than in the AMAN group. Conclusion??The incidence of the AMAN and the AIDP group is similar in north Chinese children.Compared with AIDP group??the AMAN group has seasonal characteristics and gender differences. Between the two groups?? besides sensory nerve involvement ??there was no significant difference in the clinical feature and severity. However?? the clinical progress of the AMAN is faster than the AIDP group.