升阳益胃汤预防慢性支气管炎复发及对免疫功能的影响

目的:探讨升阳益胃汤对预防慢性支气管炎复发及对免疫功能影响性。方法:选取2017年3月至2019年3月广西壮族自治区民族医院收治的慢性支气管炎反复急性发作患者98例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组49例。对照组采用常规治疗,观察组在对照组基础上加用升阳益胃汤治疗,2组患者均治疗4周。观察治疗前后免疫功能、复发次数、肺功能、炎性反应因子、临床疗效等指标变化。结果:观察组总有效率89.79%,高于对照组77.55%,差异有统计学意义(P<0.05)。治疗后2组患者炎性反应因子、CD8+、氧合指数(OI)较治疗前均下降(P<0.05),CD3+、CD4+、CD4+/CD8+、动脉肺泡氧分压比值(a/A)、第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC较治疗前升高,观察组优于对照组(P<0.05)。对照组急性发作次数、抗菌药物使用次数、中医症状积分、健康调查量表(SF-36)、补体C3、C4、免疫球蛋白A(IgA)、IgG、IgM比较差异无统计学意义(P>0.05),观察组上述指标改善优于对照组(P<0.05)。结论:升阳益胃汤可改善慢性支气管炎临床症状,其作用机制可能与提高机体免疫功能有关。

Effect of Shengyang Yiwei Decoction on Prevention of Recurrence of Chronic Bronchitis and Immune Function

To explore the effect of Shengyang Yiwei decoction on preventing recurrence of chronic bronchitis and on immune function.Methods:A total of 98 patients with recurrent acute episodes of chronic bronchitis admitted to the National Hospital of Guangxi Zhuang Autonomous Region from March 2017 to March 2019 were selected and randomly divided into control group (n=49) and observation group (n=49).The control group was treated with routine treatment,and the study group was treated with Shengyang Yiwei decoction on the basis of the control group,both for 4 weeks.The changes of immune function,frequency of recurrence,pulmonary function,inflammatory factors and clinical efficacy were observed before and after treatment.Results:The total effective rate of the observation group was 89.79%,which was higher than that of the control group (77.55%),and the difference was statistically significant (P<0.05).After treatment,inflammatory factors,CD8+ and oxygenation index (OI) decreased in both groups(P<0.05),while CD3+,CD4+,CD4+/CD8+,arterial alveolar oxygen partial pressure ratio (a/A),forced expiratory volume in the first second (FEV1),forced vital capacity (FVC) and FEV1/FVC were all increased,the observation group were significantly better than those in the control group (P<0.05).There was no significant difference in the frequency of acute attack,the use of antibiotics,TCM symptom score,SF-36,complement C3,C4,immunoglobulin A (IgA),IgG and IgM in the control group(P>0.05).The improvement of the above-mentioned indexes in the observation group was better than that in the control group(P<0.05).Conclusion:Shengyang Yiwei decoction can improve the clinical symptoms of chronic bronchitis,and its mechanism may be related to the improvement of immune function.