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Plasma colloid osmotic pressure monitoring in fluid resuscitation of pediatric patients in septic shock.

??Abstract Objective??To research the advantages of plasma colloid osmotic pressure ??COP??monitoring in fluid resuscitation of pediatric patients in septic shock. Methods??A total of 47 pediatric patients in septic shock were divided randomly into 2 groups?? all cases were dynamically monitored COP??and under went fluid resuscitation. In Group A ??22 cases???? fluid infused depending on clinical experience??and COP indexes were not considered. Only normal sodium was used in quick transfusion period. Crystal vs colloid fluid was 2??3 ?? 1 during continuing and sustaining transfusion period.In Group B ??25 cases???? if COP was lower than normal??more colloid fluid was used in quick transfusion period and Crystal vs colloid fluid was 1 ?? 1 during continuing and sustaining transfusion period??otherwise ??treatments were the same as in group A. Average artery pressure??MAP???? urine volume per hour?? central venous pressure ??cvp????fluid resuscitation volume?? usage amount of vasoactive drug??and pediatric critical illness scores ??PCIS scores?? of two groups were recorded and statistically analyzed. Results??At first??COP??PCIS scores??MAP and CVP were similar between group A and B?? COP was obviously lower than normal. Colloid fluid volume and COP of group B in every period were more than group A. Total fluid volume of group B during 6 and 24 hours were less than group A?? at 1 and 6 hour?? PCIS scores?? urine volume per hour?? MAP and CVP of group B were more than group A?? usage amount of vasoactive drug was less than group A. After 24 hours?? PCIS scores?? urine volume per hours?? MAP??CVP were similar between group A and B?? but in group B usage amount of vasoactive drug was less than that in group A. Conclusion??Monitoring COP during fluid resuscitation of pediatric patients in septic shock?? and adjusting ctystal colloid proportion depending on it ?? was helpful to increase curative effect.