缬沙坦预防阵发性房颤复发的临床研究

目的:评价缬沙坦在预防阵发性房颤复发中的疗效。方法:阵发性、症状性房颤患者91例,恢复窦性心律后,随机分为对照组45例,单纯口服胺碘酮;治疗组46例,在此基础上加服缬沙坦每天80mg,随访观察1年。结果:治疗组窦性心律维持率明显高于对照组(81.8%VS62.8%,P<0.05),左房内经明显小于对照组(35.10±10.21)mmVS(41.82±11.60)mm],差异均有显著意义。结论:缬沙坦联合胺碘酮对阵发性房颤复律后预防房颤复发维持窦性心律作用明显优于单用胺碘酮治疗,这与缬沙坦抑制肾素血管紧张素系统,降低心脏负荷,抑制心房电重构及结构重构有关,且无明显不良反应。

Clinical Study of Prevention of Recurrence of Paroxysmal Atrial Fibrillation with Valsartan

Objective:To evaluate the valsartan in the prevention of recurrence of paroxysmal atrial fibrillation efficacy.Methods: Paroxysmal,91 patients with symptomatic atrial fibrillation and restore sinus rhythm were randomly divided into control group,45 patients of oral amiodarone in the treatment group 46 patients with additional service on this basis,a daily valsartan 80mg,were followed up for one year.Results:The treatment group was significantly higher than the maintenance of sinus rhythm(81.8%VS62.8%,P<0.05),left the room by significantly less than the control group(35.10±10.21)mmVS(41.82±11.60)mm].There were significant differences.Conclusion:Valsartan combined effect of amiodarone on atrial fibrillation after cardioversion of atrial fibrillation to prevent recurrence of the role of maintenance of sinus rhythm significantly better than treatment with amiodarone,whicb inhibit the renin-angiotensin system with valsartan,reduced cardiac stress,inhibition of atrial electrical remodeling and structural remodeling related,and no obvious adverse reactions.