| 大鼠肠内菌转化间尼索地平的代谢产物 |
| |
| 引用本文： | 赵程程,张兰桐,曹亮,朱红,刘彭玮. 大鼠肠内菌转化间尼索地平的代谢产物[J]. 中国医药工业杂志, 2011, 42(3) |
| |
| 作者姓名： | 赵程程 张兰桐 曹亮 朱红 刘彭玮 |
| |
| 作者单位： | 河北医科大学药学院药物分析教研室,河北石家庄,050017 |
| |
| 基金项目： | 国家自然科学基金，河北省自然科学基金项目 |
| |
| 摘 要： | 应用LC-MS/MS法研究肠内菌转化间尼索地平的代谢产物.将间尼索地平与大鼠肠内菌于体外厌氧温孵培养,放大制备转化产率最高的代谢物.依据1H NMR和ESI-MS/MS数据确认代谢物结构,推断可能的代谢途径.结果在温孵液中发现了间尼索地平及其2种代谢产物.
|
| 关 键 词： | 间尼索地平 肠内菌 代谢 液相色谱-串联质谱 |
Metabolites of m-Nisoldipine by Rat Intestinal Flora |
| |
| ZHAO Chengcheng,ZHANG Lantong,CAO Liang,ZHU Hong,LIU Pengwei. Metabolites of m-Nisoldipine by Rat Intestinal Flora[J]. , 2011, 42(3) |
| |
| Authors: | ZHAO Chengcheng ZHANG Lantong CAO Liang ZHU Hong LIU Pengwei |
| |
| Affiliation: | ZHAO Chengcheng,ZHANG Lantong,CAO Liang,ZHU Hong,LIU Pengwei(Dept.of Pharmaceutical Analysis,School of Pharmacy,Hebei Medical University,Shijiazhuang 050017) |
| |
| Abstract: | m-Nisoldipine and its metabolites in rat intestinal flora were identified by LC-MS/MS.m-Nisoldipine was anaerobically incubated with rat intestinal flora in vitro.There were the parent drug and two metabolites in the incubation solution.The metabolites with the highest conversion yields were prepared by preparative liquid chromatography.The chemical structures of two metabolites were identified by 1H NMR and ESI-MS/MS,which inferred possible microbial transformation pathways of m-nisoldipine by rat intestin... |
| |
| Keywords: | m-nisoldipine intestinal flora metabolism LC-MS/MS |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
