| 血塞通注射液指纹图谱研究 |
| |
| 引用本文： | 薛文静,杨钊,楚敏,吴爱英. 血塞通注射液指纹图谱研究[J]. 中国药业, 2011, 20(10): 19-20 |
| |
| 作者姓名： | 薛文静 杨钊 楚敏 吴爱英 |
| |
| 作者单位： | 山东省青岛市药品检验所,山东,青岛,266071 |
| |
| 摘 要： | 目的采用超高效液相色谱-紫外检测器-质谱(UPLC/UV/MS)法对血塞通注射液进行指纹图谱研究,并对其有效成分进行定性。方法采用Waters Acquity UPLCTM BEH C18柱(100 mm×2.1 mm,1.7μm),以乙腈-10 mmol/L醋酸铵溶液进行二元线性梯度洗脱,流速0.2 mL/min。离子化模式为ESI+。结果得到了分离度和重现性均较好的血塞通注射液超高效液相色谱-紫外检测器-质谱指纹图谱,标示了8个共有峰。结论超高效液相色谱-紫外检测器-质谱法可以用于血塞通注射液的快速鉴定及质量控制。
|
| 关 键 词： | 血塞通 指纹图谱 超高效液相色谱-紫外检测器-质谱法 |
Study on Fingerprints of Xuesaitong Injection by UPLC/UV/MS |
| |
| Xue Wenjing,Yang Zhao,Chu Min,Wu Aiying. Study on Fingerprints of Xuesaitong Injection by UPLC/UV/MS[J]. China Pharmaceuticals, 2011, 20(10): 19-20 |
| |
| Authors: | Xue Wenjing Yang Zhao Chu Min Wu Aiying |
| |
| Affiliation: | Xue Wenjing,Yang Zhao,Chu Min,Wu Aiying(Qingdao Institute for Drug Control,Qingdao,Shandong,China 266071) |
| |
| Abstract: | Objective To establish a method for studying the fingerprints of Xuesaitong Injection by UPLC/UV/MS and to perform the qualitative analysis on its effective constituents.Methods The separation was performed on the Waters Acquity UPLC^TM BEH C18 column（100 mm×2.1 mm,1.7 μm）.The binary linear gradient elution was performed by the mobile phase consisting of acetonitrile-10 mmol/L NH4Ac solution with the flow rate of 0.2 mL/min.The ionization mode：ESI＋.Results The perfect fingerprints with better separating degree and better repeatability were obtained by UPLC/UV/MS,which can be used for the evaluation of Xuesaitong Injection.The eight common peaks in the fingerprints were confirmed.Conclusion The UPLC/UV/MS method can be used for the quick identification and quality control of Xuesaitong Injection. |
| |
| Keywords: | Xuesaitong fingerprints UPLC/UV/MS |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
