冠心病合并2型糖尿病患者发生阿司匹林抵抗的研究

目的:探讨冠心病(CHD)合并2型糖尿病(DM)患者的阿司匹林抵抗(AR)现象。方法:226例CHD合并2型DM患者,服用阿司匹林100mg/d×7d后,分别用二磷酸腺苷(ADP)、花生四烯酸(AA)诱导检测血小板聚集率。分析各组间临床特征、血小板活化指标的差异。结果:226例患者中AR的发生率为5.31%,阿司匹林半抵抗的发生率为31.4%;与阿司匹林敏感组相比,AR的临床特征为高密度脂蛋白减低和高甘油三酯患者居多。结论:在服用常规剂量阿司匹林的CHD合并2型DM患者中AR的发生率为5.31%,合并脂代谢异常的DM患者易发生AR或阿司匹林半抵抗。

The Study of Aspirin Resistance in Patients of Coronary Heart Disease with Type 2 Diabetes

Objective:To investigate the aspirin resistance in patients of coronary heart disease with type 2 diabetes.Methods:226 patients of coronary heart disease with type 2 diabetes,after taking aspirin 100mg/d×7d,adenosine diphosphate(ADP),arachidonic acid(AA) induced platelet aggregation were detected respectively.The differences of clinical characteristics,the Indicators of platelet activation between groups were analysised. Results:The incidence of aspirin resistance in 226 cases patients was 5.31%,the incidence of aspirin-serni-resistance was half-31.4%.Compared with the aspirin-sensitive group,the clinical characteristics of aspirin resistance were mainly in reduced high-density lipoprotein and high triglycerides in patients.Conclusions:The incidence of aspirin resistance is 5.31%in patients with coronary heart disease complicationg with type 2 diabetes who take regular doses of aspirin,diabetic patients combined with dyslipidemia are Susceptible for aspirin resistance or aspirin-semi-resistant.