| 干粉吸入剂空气动力学分散模型的建立和验证 |
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| 引用本文： | 姜力群,汤玥,鲁锡峰,陈西敬,朱家壁. 干粉吸入剂空气动力学分散模型的建立和验证[J]. 中国医药工业杂志, 2011, 42(4) |
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| 作者姓名： | 姜力群 汤玥 鲁锡峰 陈西敬 朱家壁 |
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| 作者单位： | 中国药科大学药学院,江苏,南京,210009 |
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| 基金项目： | 中央高校基木科研业务费专项资金资助，国家高技术研究发展计划(863计划) |
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| 摘 要： | 在Weiler干粉粒子聚集体全分散理论模型基础上,以硫酸沙丁胺醇为模型药物,建立了一种更加深入的千粉吸入剂空气动力学分散模型.硫酸沙丁胺醇干粉吸入剂体外沉积试验表明,该模型可预测干粉粒子的空气动力学分散行为,并可结合计算流体动力学,估算干粉吸入剂在吸入装置中的分散及微细粒子分数.
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| 关 键 词： | 干粉吸入剂 空气动力学 分散 模型 硫酸沙丁胺醇 计算流体动力学 微细粒子分数 |
Development and Validation of a Dry Powder Inhalation Aerodynamic Dispersion Model |
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| JIANG Liqun,TANG Yue,LU Xifeng,CHEN Xijing,ZHU Jiabi. Development and Validation of a Dry Powder Inhalation Aerodynamic Dispersion Model[J]. , 2011, 42(4) |
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| Authors: | JIANG Liqun TANG Yue LU Xifeng CHEN Xijing ZHU Jiabi |
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| Affiliation: | JIANG Liqun,TANG Yue,LU Xifeng,CHEN Xijing,ZHU Jiabi(School of Pharmacy,China Pharmaceutical University,Nanjing 210009) |
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| Abstract: | An improved dry powder inhalation aerodynamic dispersion model was developed based on the model introduced by Weiler for describing the complete disintegration of dry powder clusters with salbutamol sulfate as the model drug.The results of in vitro deposition experiments of salbutamol sulfate dry powder inhalation showed that the model could predict the dry powder aerodynamic dispersion behavior and estimate the dispersion behavior of a dry powder inhalation in a dry powder inhaler device and the fine parti... |
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| Keywords: | dry powder inhalation aerodynamics dispersion model salbutamol sulfate computational fluid dynamics fine particle fraction |
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