| 富马酸泰诺福韦酯的合成 |
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| 引用本文： | 吴燕,陈国华,胡杨,张明亮. 富马酸泰诺福韦酯的合成[J]. 中国医药工业杂志, 2011, 42(2) |
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| 作者姓名： | 吴燕 陈国华 胡杨 张明亮 |
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| 作者单位： | 中国药科大学药物化学教研室,江苏南京,210009 |
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| 摘 要： | 腺嘌呤与(R)-环氧丙烷缩合得(R)-9-(2-羟基丙基)腺嘌呤,经醚化、水解得到泰诺福韦,再经氯甲基碳酸异丙酯酯化、成盐制得抗病毒药富马酸泰诺福韦酯,总收率约21%.
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| 关 键 词： | 富马酸泰诺福韦酯 抗病毒药 合成 |
Synthesis of Tenofovir Disoproxil Fumarate |
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| WU Yan,CHEN Guohua,HU Yang,ZHANG Mingliang. Synthesis of Tenofovir Disoproxil Fumarate[J]. , 2011, 42(2) |
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| Authors: | WU Yan CHEN Guohua HU Yang ZHANG Mingliang |
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| Affiliation: | WU Yan,CHEN Guohua~*,HU Yang,ZHANG Mingliang (Dept.of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009) |
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| Abstract: | Tenofovir disoproxil fumarate was synthesized from adenine via ring-opening condensation with (R) -propylene oxide,etherification and hydrolysis to give tenofovir,which was subjected to reaction with chloromethyl isopropyl carbonate,followed by salt formation with an overall yield of about 21%. |
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| Keywords: | tenofovir disoproxil fumarate antiviral drug synthesis |
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