| 阿卡波糖片的亲水色谱法测定 |
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| 引用本文： | 谢赞,杜旭召,何丽娟,陈玉洁,史颖.阿卡波糖片的亲水色谱法测定[J].中国医药工业杂志,2011,42(2). |
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| 作者姓名： | 谢赞 杜旭召 何丽娟 陈玉洁 史颖 |
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| 作者单位： | 石药集团中奇制药技术(石家庄)有限公司,河北石家庄,050051 |
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| 摘 要： | 建立了亲水色谱法测定阿卡波糖片的含量及其有关物质.采用Phenomenex氨基柱,以6 mmol/L磷酸二氢钾缓冲液(pH 6.8)-乙腈(28:72)为流动相,检测波长210nm.阿卡波糖在4～20mg/ml浓度范围内线性关系良好.平均回收率为99.2%,RSD为0.7%.
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| 关 键 词： | 阿卡波糖 片剂 亲水色谱 测定 |
Determination of Acarbose Tablets by Hydrophilic-interaction Chromatography |
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| Authors: | XIE Zan DU Xuzhao HE Lijuan CHEN Yujie SHI Ying |
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| Institution: | XIE Zan,DU Xuzhao,HE Lijuan,CHEN Yujie,SHI Ying~* (Shijiazhuang Pharm Group Zhongqi Pharmaceutical Technology(Shijiazhuang) Co.,Ltd.,Shijiazhuang 050051) |
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| Abstract: | A hydrophilic-interaction chromatography method was established for the determination of acarbose tablets and its related substances.A Phenomenex NH_2 column was used with the mobile phase of 6 mmol/L potassium dihydrogen phosphate buffer(pH 6.8) -acetonitrile(28:72),at the detection wavelength of 210 nm.The calibration curve was linear in the concentration range of 4-20 mg/ml.The average recovery was 99.2%with RSD of 0.7%. |
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| Keywords: | acarbose tablet hydrophilic-interaction chromatography determination |
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