肝硬化患者肠道去污、调整肠道微环境治疗前后血清内毒素及IL-6水平的变化

目的：观察晚期肝硬化患者肠道去污，调整肠道微环境治疗前后血清同位素,IL-6水平的变化以及自发性细菌性腹膜炎（SBP）的发生率。寻找一种能够更有效降低SBP发生率的方法。方法：A组：给予保肝，补充人体白蛋白，利尿等常规治疗；B组：在常规治疗的基础上每2周给予氟哌酸（FPA）0．2g,tid,po，连服3d;C组在B组治疗的基础上，停用FPA后给予肠复康0．5g,tid,po，肠泰口服液10ml,tid,po.乳果糖10ml,tid,po，共8周，结果：A组治疗前后血清内毒及IL－6水平无明显变化，SBP发生率明显高于B，C组；B组治疗后血清内毒素及IL－6下降，SBP发生率降低；C组治疗后血清内毒素及IL－6明显下降，SBP发生率明显降低，与A，B组比较差异均有显著性。／结论：肠道去污，调整肠道循环境治疗可有效的降低内毒素血症及IL－6水平，使SBP发生率明显降低。

Changes of Serum Endotoximia and Interleukin-6 Levels Before and After Treatment at Intestine Depollution and Adjustment Intestine Microenvironment in Patients With Liver Cirrhosis

Objective To observe the changes of serum endotoxin and interleukin-6 level before and after treatment at intestine get rid of filth and adjustment intestine microenviroment in patients with advanced stage liver cirrhosis and to oberserve the incidence of spontaneous bacterial peritonitis(SBP) and to research a method that can more efficient reduce the incidence of SBP.Methods Group A was given conventional treatment such as protection liver,supplement human albumin and uragogue;goup B was given FPA 0 2g tid po,continuous three days on the basis of two weeks conventional treatment,group C was given Tab comfort get 0 5g tid po,Changtai orally taken liquid,10ml tid po,lactulose 10ml tid po, for all 8 weeks,on the basis of group B treatment after pausing use FPA.Results Serum endotoxin and interleukin-6 levels in group A was not significantly changes after treatment,,SBP incidence was higher than both group B and group C;at group B,serum endotoxin and interleukin-6 levels decline,SBP incidence significantly drop afer treatment,at group C,serum endotoxin,interleukin-6 level and SBP incidence significantly drop,the difference was significant at statistics as compared with group A and B.Conclusions The treatment at intestine get rid of filth and adjustment intestine microenviroment can effectively reduce serum endotoxin and interleukin-6 levels and can significantly reduce the incidence of SBP.