首页 | 本学科首页   官方微博 | 高级检索  
检索        

竹节人参提取物对异丙肾上腺素致大鼠急性心肌缺血损伤的保护作用
引用本文:刘家兰,李德清,段先宇.竹节人参提取物对异丙肾上腺素致大鼠急性心肌缺血损伤的保护作用[J].湖北民族学院学报(医学版 ),2004,21(3):13-15.
作者姓名:刘家兰  李德清  段先宇
作者单位:湖北民族学院医学院实验中心,湖北,恩施,445000;湖北民族学院医学院实验中心,湖北,恩施,445000;湖北民族学院医学院实验中心,湖北,恩施,445000
摘    要:目的:研究竹节人参提取物对异丙肾上腺素(ISO)致大鼠急性心肌缺血的保护作用及机制。方法:采用大剂量ISO皮下注射(SC)诱导产生大鼠急性心肌缺血模型(ISO30mg/kg,每日一次,连续2d),实验大鼠随机分为正常组、ISO模型组、阳性对照组、竹节人参提取物(0.15,0.3g/kg)给药组,测定心脏系数和血清中乳酸脱氢酶(LDH)、磷酸肌酸激酶(CK)和丙二醛(MDA)含量,观察心肌组织谷胱甘肽过氧化物酶(GSH-Px)、Na^ -K^ -ATP酶和Ca^2 -Mg^2 -ATP酶活性。结果:竹节人参提取物能显著降低血清中CK和LDH的释放;也能显著降低血清和心脏匀浆中MDA水平,心脏系数显示对心肌水肿有明显的抑制作用:保护心肌GSH-Px;Na^ -K^ -ATP酶和Ca^2 -Mg^2 -ATP酶活性。结论:竹节人参提取物对ISO所致大鼠急性心肌缺血有显著的保护作用。其机制与抗自由基、抑制脂质过氧化反应有关。

关 键 词:竹节人参  异丙肾上腺素  心肌缺血  保护作用
文章编号:1008-8164(2004)03-0013-03
修稿时间:2004年6月10日

Protective Effect of Panax Japonicus C.A.Meyer on Isoproterenol-induced Myocardial Injury in Rats
LIU Jia-lan,LI De-qing,DUAN Xian-yu.Protective Effect of Panax Japonicus C.A.Meyer on Isoproterenol-induced Myocardial Injury in Rats[J].Journal of Hubei Institute For Nationalities(Medical Edition),2004,21(3):13-15.
Authors:LIU Jia-lan  LI De-qing  DUAN Xian-yu
Abstract:Objective To study the protective effect of Panax japonicus C.A.Meyer on myocardial ischemia induced by isoproterenol(ISO).Methods Myocardial ischemia was induced dy subcutaneous injection of ISO (30 mg/kg for two days,once a day). The experimental animals were randomly divided into the normal group, ISO group,positive control group and two Panax japonicus C.A.Meyer groups (0 15,0 3 g/kg).Cardiac indexes were examined.The level of LDH,CK,MDA in serum were measured.The activity of MDA,GSH-Px and the ATPase positive of heart tissue were assayed by colorimetric analysis.Results Compared with the model group,Panax japonicus C.A.Meyer can significantly reduce the cardiac indexes,obviously decrease the level of MDA,LDH and CK in the serum.Panax japonicus C.A.Meyer can significantly increase the activities of Na +-K +-ATPase; Ca 2+ -Mg 2+ -ATPase;GSH-Px.Conclusion Panax japonicus C.A.Meyer Could alleviate the acute myocardial ischemia induced by isoproterenol-induced in rats.
Keywords:Panax  japonicus  C  A  Meyer  isoproterenol(ISO) ISO  myocardial ischemia  proteetive effcct
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号